Perinatal Depression & Anxiety (PDA) and Maternal Gut Microbiome

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• 18 és 43 év között vagy?IgenNem

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Perinatal depression and anxiety (PDA) are the leading causes of maternal mortality in developed countries. Women with a history of depression have a 20 fold higher risk of PDA at subsequent pregnancies. The adverse outcomes extend beyond maternal well-being to long-term deficits in children and families. The gut-brain axis is a newly recognized key player in mental health disorders. Specifically, the microbial composition of the gut along with their metabolites are directly involved in disease onset and course. Recent clinical studies have identified diet as the most powerful environmental factor in manipulating gut microbiome. Given vulnerability and resistance of pregnant women to pharmacotherapy, particularly in those with a predisposition to mood disorders, as well as pregnant women's high motivation and commitment to improving gestational diet, a dietary/supplemental intervention to 'optimize' gut microbiome, is a favored approach in disease management. The study investigators aim to exploit microbial responsiveness to diet together with this maternal motivation, to alter the risk and severity of a universal public health concern that has dire and long-term consequences for new moms and their children.

A vizsgálat 4 csoportja

• GutopiaA vizsgált kezelés

  Women in this arm will receive dietary modification, fish oil and probiotics from the time of enrollment till completion of last study visit (12 months postpartum). The dietary modification will be conducted by a dietician that will provide feedback on the participants diet at enrollment, ways to improve diet quality to meet pregnancy needs, and increase prebiotic foods. Weekly follow-ups will be conducted by the research team to ensure dietary target is met and to help address challenges in doing so. The initial dietary consult will be 30-45 minutes long with 10-15 minute for each subsequent follow-up.

  Kezelés: Fish oil, Probiotics és Prebiotics

• GutboostA vizsgált kezelés

  Women in this arm will receive a daily probiotic and fish oil supplement from the time of enrollment till 1 year postpartum.

  Kezelés: Fish oil és Probiotics

• GutlessA vizsgált kezelés

  Women in this arm will receive fish oil and placebo probiotic from the time enrollment till 1 year postpartum .

  Kezelés: Fish oil

• GutnoneMár használt kezelés, összehasonlításként

  Women in this arm will only be receiving standard care by their obstetrician, and a one time, 30 minutes consult on how to improve baseline diet quality to meet pregnancy needs will be provided by a dietician at the time of enrollment.

  Kezelés: Diet Quality