Safety Profile of Psilocybin for Cocaine Use Disorder

Ki vehet részt

• Have a Body Mass Index from 18.5 - 34kg/m\^2
• Score of at least 3 on the Severity of Dependence Scale
• Desire to cease cocaine use as indicated by a goal of complete cocaine abstinence on the Thoughts about Abstinence Questionnaire
• At least 1, but not more than 10 total lifetime use of a classical psychedelic (5-HT2a agonist)
• 0 use of a classical psychedelic in the last year

Ki nem vehet részt

• History of serious adverse events in response to classical psychedelics including history of Hallucinogen Persisting Perceptive Disorder
• A resting heart rate greater than 90 bpm
• Current hypertension (exceeding 140 systolic and 90 diastolic at resting)
• History of cardiac conditions
• History of hepatic or renal impairments
• History of stroke or Transient Ischemic Attack
• Epilepsy or history of seizures
• Immediate family or personal history of psychosis, bipolar disorder, or schizophrenia
• Anxiety or mood disorders determined by the Diagnostic and Statistical Manual of Mental Disorders 5 (DSM-V)
• Must not meet DSM-V criteria for any substance use disorders other than cocaine, caffeine, or nicotine
• Must not meet DSM-V criteria for borderline personality or dissociative disorders
• Current suicidal ideation or lifetime history of suicide attempts
• Any clinical condition, history of illness, or laboratory results that may place participants at greater risk as judged by the study physician
• Abnormal electrocardiogram based on testing at study entrance
• Current use of antidepressants or other serotonergic-affecting substances
• Arrest for a violent offense
• Women will not be eligible if trying to get pregnant, pregnant, or lactating