Efficacy of MindAhead's Digital Behavioral Activation Therapy in Adults with MCI or Mild Dementia

Ki vehet részt

• Diagnosis of cognitive impairment in MCI stage (ICD-10 codes: F06.7, F07.8) or mild dementia stage (ICD-10: F00.-*, F01.-, F03) due to all etiologies apart from etiologies described in F02.- (Pick's disease, Parkinson's disease, multiple sclerosis, Huntington's disease, HIV, Lewy body disease). Hence, etiologies of MCI and mild dementia include; Alzheimer's disease (e.g., F00.-*); Vascular disease (e.g., F01.-) (exception in case of stroke: event occurred > 12 months ago without ongoing spontaneous remission); Mixed diseases; Unclear etiologies
• MCI or mild dementia diagnosis assigned within the last 12 months by a neurologist or psychiatrist from our cooperation partners that fulfil adequate diagnosis procedures such as neuropsychological assessment, brain imaging, self- and/or third-party medical history interview, and potentially cerebrospinal fluid, positron emission tomography, or electrophysiological measures
• MCI or mild dementia diagnosis confirmed by a treating physician
• MMSE ≥ 24 or MoCA ≥ 18 (last date of assessment is decisive; needs to be within the last 12 months)
• Sufficient physical fitness to engage in physical activities (e.g., walking or cycling) as confirmed by a treating physician
• Age ≥ 50
• German language skills sufficient to understand German instructions of study assessments and of the intervention
• Ability and sufficient vision to operate a smartphone

Ki nem vehet részt

• possibly moderate or severe cognitive impairment (moderate or severe dementia), indicated by MMSE < 24 or MoCA < 18 (last date of assessment is decisive; needs to be within the last 12 months)
• Specific brain injury events within the last 12 months or with ongoing spontaneous remission due to; Stroke (ischemic, hemorrhagic); Traumatic brain injury
• Specific etiologies of MCI or mild dementia (F02.-) that show a variable course or a fast progression including; Multiple sclerosis; Parkinson's disease; Pick's disease / Frontotemporal lobar degeneration; Lewy body disease; Brain tumors; Autosomal dominant form of Alzheimer's disease with early first manifestation; Creutzfeldt-Jakob disease
• German language restrictions or visual restrictions which prevent from understanding written German instructions of assessment or intervention procedures (e.g. severe aphasia, lack of sufficient German language skills, severe non-corrected visual impairment)