7 Tesla MRI Neuroimaging in Testicular Cancer Patients With Hypogonadism and on Androgen Replacement Therapy
A legfontosabb adatok
- Ki végzi
- University of Southern California
- Hol
- Los Angeles (Egyesült Államok)Mind a 2 helyszín megnézése
- Azonosító
- Állapot
- Felfüggesztve
- Résztvevők
- 10 fő, tervezett
- Kezdés
- 2022. nov. 29.
- Várható befejezés
- 2027. dec. 31.
- A vizsgálat típusa
- Megfigyeléses
- A vizsgált kezelések
- 7 Tesla Magnetic Resonance Imaging
- Biospecimen Collection
- Cognitive Assessment
- A regiszteradat frissítve
- 2026. június 5.
- Miért állt le
- Study team is conducting interim analysis.
Ki vehet részt
- Életkor
- 18 év felett
- Nem
- Csak férfiak
- Egészséges önkéntesek
- Nem vehetnek részt
A regiszter feltételei, szó szerint
Mind a 10 feltétel megnézéseKevesebb
Ki vehet részt
- Males age >= 18 years
- Diagnosed with germ cell tumor of the testis (seminoma or non-seminoma) and treated with radical orchiectomy
- Diagnosed with hypogonadism and started androgen replacement therapy 6 months prior (+/- 2 weeks)
- Ability to understand and the willingness to sign a written informed consent
- Ability to undergo imaging procedure without any form of sedation
Ki nem vehet részt
- History of ART prior to current ART regimen
- Standard contraindications for MRI:; Prior work as a machinist or metal worker, or history of metal being removed from the eyes; Cardiac pacemaker or internal pacing wires; Non-MRI compatible vena cava filter, vascular aneurysm clip, heart valve, spinal or ventricular shunt, optic implant, neuro-stimulator unit, ocular implant, or intrauterine device, or; Claustrophobia, or uncontrollable motion disorder
- History of any neuropsychiatric disease
- History of narcotic use or psychiatric medications
- Current active second malignancy
Helyszínek itt: Egyesült Államok
- Los Angeles General Medical CenterLos Angeles, Egyesült Államok
- USC / Norris Comprehensive Cancer CenterLos Angeles, Egyesült Államok
A vizsgálatról
Mit akar kideríteni a vizsgálat
This study evaluates 7 Tesla (T) magnetic resonance imaging (MRI) in observing changes in the brain (neuroimaging) in testicular cancer patients who have decreased testosterone (hypogonadism) and are on testosterone (androgen) replacement therapy. Symptoms of hypogonadism can include fatigue, weakness, loss of libido, depression, poor concentration and erectile dysfunction. Some patients experience mental changes after diagnosis and treatment. There is some evidence that hypogonadism produces structural changes in the brain. The 7T MRI uses radio waves and a very powerful magnet linked to a computer to create detailed pictures of areas inside the body. This study may help researchers learn if 7T MRI can produce better images to assess the changes in the brain structure of testicular patients with hypogonadism and on androgen replacement therapy (ART).
A vizsgálat csoportja
- Observational (7T MRI, cognitive assessment, blood collection)
Patients undergo 7T MRI over 1-2 hours at baseline and at 12 months after baseline. Patients also undergo a proctored cognitive assessment over approximately 1 hour prior to each MRI. Additionally, patients undergo blood sample collection at screening and at 12 months after baseline MRI.
Kezelés: 7 Tesla Magnetic Resonance Imaging, Biospecimen Collection és Cognitive Assessment
Adatok és források
- Regiszteradat
- Szerepel a ClinicalTrials.gov-on.
- Hivatalos cím
- A Pilot Study of 7 Tesla MRI Neuroimaging in Testicular Cancer Patients With Hypogonadism and Androgen Replacement Therapy
- A regiszteradat frissítve
- 2026. június 5.