A Mechanistic Trial of the Neurobiology of Extinction Learning and Intraparietal Sulcus Stimulation

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This study will be the first of its kind to explore the impact of continuous theta burst stimulation (cTBS) to the intraparietal sulcus (IPS) on arousal symptoms among patients with posttraumatic stress disorder (PTSD). The investigators will demonstrate that IPS cTBS results in significant reduction in arousal (measured by startle response) compared to sham cTBS, that IPS cTBS interacts with extinction training to further improve arousal, and that there is a dose/response effect of cTBS on arousal. The investigators will also demonstrate that IPS cTBS significantly improves retention of extinction learning, the experimental analogue of exposure therapy.

A vizsgálat 2 csoportja

• Continuous theta burst stimulation to the intraparietal sulcusA vizsgált kezelés

  Continuous theta burst stimulation will be delivered to the individually targeted intraparietal sulcus site at 100% RMT.

• Sham continuous theta burst stimulationPlacebo, összehasonlításként

  We will use the coil's electric stimulation functionality that allows for the delivery of a brief electric pulse to the scalp simultaneous to the pulse to mimic actual stimulation.