Phenotyping of Postural Orthostatic Tachycardia Syndrome (POTS)
A legfontosabb adatok
- Hol
- Dallas (Egyesült Államok)A helyszín megnézése
Helyszínek itt: Egyesült Államok
- UT Southwestern Medical CenterDallas, Egyesült ÁllamokContact: Steven HopkinsRésztvevőt keres
Kérdések a vizsgálat csapatának
- Milyen gyakran kell bejárnom, és egy-egy alkalom mennyi ideig tart?
- Megtérítik az utazási költséget?
- Megtarthatom a saját orvosomat?
- Mi történik, ha ki akarok lépni?
Contact the study team: see the registry record → Contacts and Locations
Oldal nyomtatása az orvosomnakA vizsgálat adatai
- Ki végzi
- University of Texas Southwestern Medical Center
- Azonosító
- NCT06292104
- A regiszteradat frissítve
- 2026. július 17.
- Eredeti leírás
This is an observational study to deeply phenotype the disorder of POTS using multiple testing modalities.A teljes eredeti leírásKevesebb
Multimodality Deep Phenotyping of Postural Orthostatic Tachycardia Syndrome (POTS), Aim 1
This is an observational study to deeply phenotype the disorder of POTS using multiple testing modalities.
Bevonási feltételek: POTS Patients; Age ≥ 14 years, able to provide informed consent (assent with parental consent for age < 18) and comply with procedures; Meets consensus criteria for POTS: (1) sustained increase in heart rate ≥ 30 bpm above supine baseline within 10 min of quiet standing or upright tilt (≥ 40 bpm in individuals 12 to 19 years of age) OR sustained upright HR (heart rate) >120 bpm, (2) absence of orthostatic hypotension, (3) symptoms with standing that improve with sitting or lying down, (4) resting supine heart rate < 100 bpm, (5) orthostatic symptoms present for at least 6 months; Stable oral medication regimen for at least 14 days; Non-POTS Control Patients; Healthy women, age 18 - 30 years, able to provide informed consent and comply with study procedures; Does NOT meet consensus criteria for postural tachycardia syndrome; No symptoms of orthostatic intolerance or dysautonomia. No history of other major medical disorder; Resting supine heart rate < 100 bpm.
Kizáró feltételek: Use of amphetamine-type stimulants, diuretics, selective norepinephrine reuptake inhibitor, anticholinergic medications (including tricyclic antidepressant medications), fludrocortisone, desmopressin in past 14 days; Use of other autonomic drugs (adrenergic agents, pyridostigmine, droxidopa, triptans, ivabradine) in past 48 hours; Currently receiving IVIG (Intravenous immunoglobulin), subcutaneous IgG (Immunoglobulin G), or any investigational medication (in past year); History or evidence of another condition explaining symptoms or orthostatic tachycardia (e.g. structural heart disease, CSF (Cerebrospinal fluid) hypovolemia, or severe traumatic brain injury); None of the following exclusion criteria:; Infusion of iv fluids in past 7 days.