Study of Injectable Naltrexone and Oral Bupropion Among Cigarette Smokers With Schizophrenia

Ki vehet részt

• fluent in English
• Diagnosed with schizophrenia spectrum disorder that is currently stable
• Report regular cigarette smoking, average cigarette per day ≥ 5 in the past 4 weeks, and present a breath CO≥10 ppm
• Meet subjective and objective (urinary drug screen) measures of non-opioid use
• If female, present a negative pregnancy test, not be currently breast feeding, and agree to use acceptable birth control methods and receive periodic pregnancy tests during the course of the study
• Able to give written informed consent
• Obtain an Evaluation to Sign Consent (ESC) score above 10

Ki nem vehet részt

• Previous use of bupropion or naltrexone in the past 30 days
• Be medically unstable or taking medications that are contraindicated with using naltrexone or bupropion
• Meet Diagnostic and Statistical Manual of Mental Disorders (DSM-5 )criteria for alcohol and other substance use disorders excluding nicotine and marijuana
• Report a history of epilepsy, seizure disorder or condition increasing risk of seizure, or head trauma with neurological sequelae
• Have a current eating disorder
• Have suicidal or homicidal ideation requiring immediate attention
• Currently enrolled in treatment for tobacco use