Dose Optimization of MDMA-Assisted Therapy for PTSD

Ki vehet részt

• Are a U.S. military veteran at least 18 years old
• Are able to provide written, informed consent
• Are able to swallow pills
• Agree to have study visits recorded, including Experimental Sessions, psychological assessments, and non-drug therapy sessions
• Must provide a contact who is willing and able to be reached by the investigators in the event of a participant becoming unwell or unreachable
• If able to become pregnant, must have a negative pregnancy test at study entry and prior to each Experimental Session, and must agree to use adequate contraceptive methods
• Must have a current PTSD diagnosis at screening and baseline
• Must not participate in any other interventional clinical trials for the duration of the study
• Must commit to medication dosing, therapy, and all study procedures

Ki nem vehet részt

• Have a history of any medical condition, or any significant clinical finding on screening tests, that could make receiving a sympathomimetic drug harmful
• Abusing illegal drugs or alcohol
• Have received Electroconvulsive Therapy (ECT) or ketamine therapy within 12 weeks of enrollment
• Have uncontrolled hypertension
• Have evidence or history of significant medical or psychiatric disorders
• Have symptomatic liver disease
• Have history of hyponatremia or hyperthermia
• Unable or unwilling to safely taper off prohibited psychiatric medication
• Are not able to give adequate informed consent
• Weigh less than 48 kilograms (kg)
• Are pregnant or nursing or are able to become pregnant and are not practicing an effective means of contraception