Sex Differences in Trauma, Inflammation and Brain Function and the Implications for Treatment Efficacy in Alcohol Use Disorder

Ki vehet részt

• 18-60 years old
• Veteran enrolled in VHA healthcare; Alcohol Group:
• must meet diagnosis for recent alcohol-use disorder (DSM-V)
• willing to return for follow-up visits and can participate for 12-weeks; Control Group:
• must not meet DSM-V criteria for a use disorder other than nicotine

Ki nem vehet részt

• Recreational or prescriptive use of psychotropic medications
• Positive urine drug screen, except for nicotine and marijuana, on test days
• Participants on hormonal therapy or treatments other than pregnancy contraceptives
• Current participation in an investigational drug study
• Clinically significant neurological, endocrine, hepatic, or systemic disease that would compromise safe participation or confound outcomes
• Axis-1 psychiatric diagnoses other than anxiety, depression or post-traumatic stress disorder
• Recreational or prescriptive use of opioid medications or have a past or current history of abuse or dependence on opioids
• Autoimmune or neurodegenerative diseases that present with neuroinflammation (multiple sclerosis, amyotrophic lateral sclerosis, Alzheimer's, Parkinson's)
• Alcohol group: Liver disease requiring medication or medical treatment, and/or aspartate or alanine aminotransferase levels greater than 3 times the upper limit of normal, gastrointestinal or renal disease that would significantly impair absorption, metabolism or excretion of study drug, or require medical treatment
• Left-handedness
• MRI contraindications (e.g. metal in body)
• Women who are pregnant or breastfeeding
• Alcohol group: < 5 days and > 3 weeks of abstinence from alcohol
• Non-english speaker