Mind-wandering and Predictive Processes in Narcolepsy: a Putative Mechanism Through Covert REM Intrusions

MI-összefoglaló

A vizsgálat saját részvételi feltételeiből. Gép olvasta ki az oldalon álló regiszterszövegből, ezért tévedhet. Hogy ki vehet részt, azt a lenti regiszterszöveg és a vizsgálat csapata dönti el.

The trial is looking for adults with narcolepsy type 1, idiopathic hypersomnia, or excessive sleepiness with no cause found. It studies mind-wandering during a computer task.

Életkor

18 Years to 65 Years

Nem

All sexes

A betegség stádiuma

Narcolepsy type 1 or idiopathic hypersomnia diagnosed by ICSD3-TR criteria. Or excessive sleepiness felt by the person, with a full work-up finding no cause.

Korábbi kezelés

People taking an antidepressant cannot join.

Biomarker vagy leletérték

For idiopathic hypersomnia: abnormal Mean Sleep Latency Test (MSLT), mean latency ≤ 8 min, ≤ 1 SOREMp.

A részvétel fő kizáró okai

• Problems with thinking or memory that make the task impossible
• Treatment with an antidepressant
• Other cause of sleepiness, such as untreated severe obstructive sleep apnea, body clock disorders, lack of sleep or sedative drugs
• Unstable medical or psychiatric condition
• Refusal to take part

A regiszter feltételei, szó szerint

Nézd meg, megfelelhetsz-e

Magadról válaszolj. Ez nem döntés: hogy részt vehetsz-e, azt csak a vizsgálat csapata mondhatja meg.

• 18 és 65 év között vagy?IgenNem

Mit akar kideríteni a vizsgálat

Mind wandering is a state in which attention turns away from the external environment or current task to focus on internal thoughts (past experiences, future events, planned actions...). Humans are thought to spend at least one third of their waking lives in this state. Mind wandering can be assessed experimentally by investigating mental content during well-controlled tasks. In this case, task-unrelated thoughts likely to arise during tasks of varying cognitive demand are studied. Mind wandering (=task-unrelated thoughts) has a deleterious effect on cognitive performance in most paradigms, particularly those requiring sustained attention and executive control. However, this phenomenon could also have cognitive benefits, although knowledge on this issue remains limited. For example, it has been suggested that mind wandering could promote creativity, anticipation of future scenarios and prospective memory. In a recent behavioural study, we investigated the cost and benefit of mind wandering in an implicit visual-motor probabilistic learning task (ASRT - Alternating Serial Reaction Time Task). ASRT distinguishes between two fundamental processes: visuomotor performance and implicit statistical learning. While the former reflects visuo-spatial discrimination efficiency, the latter refers to the unintentional acquisition of probabilistic regularities of external inputs. Reduced visuo-spatial accuracy and faster but less accurate responses have been observed during periods of mind-wandering. On the other hand, mind-wandering was associated with enhanced statistical learning reflecting improved predictive processing.

A vizsgálat 3 csoportja

• Narcolepsy type 1A vizsgált kezelés

  Patients with narcolepsy type 1 according to International Classification of Sleep Disorders (ICSD3-TR) criteria; they will have to fill study questionnaires and perform the ASRT. A subset of patients will undergo polysomnography recording (EEG, EOG, EMG, ECG) during the ASRT.

  Kezelés: ASRT, Questionnaires és Electrophysiological recordings

• Idiopathic hypersomniaA vizsgált kezelés

  Patients with Idiopathic hypersomnia according to ICSD3-TR and with mean sleep latency ≤8min at the multiple sleep latency test (MSLT) (whatever total sleep time/24h bedrest); they will have to fill study questionnaires and perform the ASRT. A subset of patients will undergo polysomnography recording (EEG, EOG, EMG, ECG) during the ASRT.

  Kezelés: ASRT, Questionnaires és Electrophysiological recordings

• Subjective hypersomnolenceMár használt kezelés, összehasonlításként

  Patient with subjective hypersomnolence without underlying cause (negative extensive work-up including actigraphy, polysomnography (PSG), MSLT, 24h bedrest, biological tests, MRI, psychiatric consultation; this allows to rule out sleep deprivation, irregular sleep/wake schedule, sleep apnea or other sleep disorders associated with sleep fragmentation, somatic/psychiatric causes of hypersomnolence, sedative substance intake). A subset of patients will undergo polysomnography recording (EEG, EOG, EMG, ECG) during the ASRT. They will have to fill study questionnaires and perform the ASRT.

  Kezelés: ASRT, Questionnaires és Electrophysiological recordings