A Phase 1 Open-Label Study of the Safety of Intravenous Allogeneic Neonatal Mesenchymal Cells (nMSCs) in Young Adult (1A) and Pediatric (1B) Patients With Dilated Cardiomyopathy (DCM)

A vizsgálat adatai

Ki végzi

Emory University

Azonosító

NCT06464588

A regiszteradat frissítve

2026. június 26.

Eredeti leírás

This is a Phase 1 study to determine the safety and efficacy of allogeneic neonatal mesenchymal stromal cells (nMSCs) for the treatment of Dilated Cardiomyopathy. The purpose of the study is to help doctors and scientists learn if allogeneic neonatal mesenchymal stromal cells (nMSCs) infusions are a safe and effective way to improve cardiac function and left ventricular ejection fraction.A teljes eredeti leírásKevesebb

This is a Phase 1 study to determine the safety and efficacy of allogeneic neonatal mesenchymal stromal cells (nMSCs) for the treatment of Dilated Cardiomyopathy. The purpose of the study is to help doctors and scientists learn if allogeneic neonatal mesenchymal stromal cells (nMSCs) infusions are a safe and effective way to improve cardiac function and left ventricular ejection fraction.

Bevonási feltételek: Phase 1A: Age greater than or equal to 16 years and less than 40 years (≥16 years, <40 years); Phase 1B: Age greater than or equal to 4 years and less than 16 years (≥4 years, <16 years); Subjects must be able to sign their own consent for Phase 1A of the study; Diagnosis of dilated cardiomyopathy (DCM) defined as; Any Congenital Cardiac Malformation with systemic ventricular systolic dysfunction; Idiopathic Cardiomyopathy; Familial/Inherited and/or Genetic Cardiomyopathy; History of Myocarditis; Acquired (Chemotherapy, Iatrogenic, Infection, Rheumatic, Nutritional); Ischemic (e.g. Kawasaki Disease, post-operative); Left ventricular noncompaction; Coronary Artery Disease; Left ventricular ejection fraction less than or equal to 45% documented by two-dimensional echocardiogram or cardiac MRI within the prior six months; Left ventricular dilation as defined by echocardiography left ventricular and end-diastolic dimension Z score > +2.0; Biventricular physiology with systemic left ventricle; Must receive guideline directed heart failure as defined by the American Heart Association, American College of Cardiology, and Heart Failure Society of America 118; Have been unresponsive or poorly responsive to at least 3 months of maximum guideline directed treatments.

Kizáró feltételek: Previous heart transplant recipient; Currently on extracorporeal membrane oxygenation support; Immune system-altering medications, or immunosuppressive therapy at the time of enrolment or within the prior 12 weeks; Presence of HLA antibodies specific for therapeutic study product; Listed for heart transplantation (as UNOS status 1A) or hospitalized while waiting for transplant (while on inotropes or with ventricular assist device); Cardiovascular surgery of percutaneous intervention to palliate or correct congenital cardiovascular malformations within 3 months of the screening visit. Patients anticipated to undergo corrective heart surgery during the 12 months after entry into Part 1A/1B; Unoperated primary obstructive or severe regurgitant valve (aortic, pulmonary, mitral or tricuspid) disease, or significant systemic ventricular outflow obstruction or aortic arch obstruction anticipated to require surgical or transcatheter intervention within 6 months; Lethal, uncontrollable arrhythmia defined as an arrhythmia resulting in hemodynamic instability requiring need for defibrillation, continuous intravenous anti-arrhythmic medication or mechanical circulatory support; Clinical history of malignant neoplasm within 5 years (with the exception of curatively treated basal cell carcinoma, squamous cell carcinoma, or cervical carcinoma); Serious neurologic disorder including loss of vision, stroke, or paralysis; High-grade pulmonary embolism requiring interventional catheter procedure or pulmonary hypertension requiring use of pulmonary vasodilators including phosphodiesterase inhibitor or nitric oxide; Multiple organ failure; Non-cardiac condition that limits life span for <1 year; Active infection (including endocarditis) requiring pharmacotherapy; Active hemorrhagic disease (e.g., gastrointestinal bleeding, injury); History of cardiac transplantation; History of noncompliance, alcohol abuse, recreational drug use, or incarceration within the last year; High-grade renal failure [eGFR<45] mL/min/1.73 m2 - serum potassium >5.3 mmol/L; Uncontrolled diabetes (HbA1c >9%) at screening; Elevated WBC greater than upper limit of normal as defined by local lab at time of consent; Restrictive or hypertrophic cardiomyopathy; Cardiogenic shock; Ventricular assist device support; Patients with persistent atrial fibrillation requiring specific pharmacotherapy; Amyloidosis; Ischemic dilated cardiomyopathy; Sepsis; Dystrophin-associated cardiomyopathy confirmed by standard cardiomyopathy panel testing; Confirmed myocarditis at time of screening; Elevated LFTs greater than 2 times upper limit of normal at time of consent; Currently pregnant or breastfeeding; Unsafe/unfeasible to enroll due to PI/designee discretion.

ClinicalTrials.gov NCT06464588