CES and EGChatbot in Reducing Anxiety, Depression, Insomnia, and Mental Risk

MI-összefoglaló

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The trial is looking for adults aged 18 to 65 at high risk of developing a serious mental illness (called ARMS, at-risk mental state). They test an exercise chatbot app, mild electrical brain stimulation (CES), or both, for 16 weeks.

Életkor

18 Years to 65 Years

Nem

All sexes

A betegség stádiuma

Must meet the DSM-5 criteria for ARMS, checked by the study psychiatrists. Symptoms must be ongoing, without large ups and downs.

A részvétel fő kizáró okai

• Intellectual disability, or alcohol or drug use disorder
• History of epilepsy, head injury, brain or nerve disease, or frequent fainting
• Pregnant or breastfeeding
• Implanted nerve stimulator, heart pacemaker, metal implants, or a cochlear implant that cannot be removed
• Unable to follow the study plan, including having no computer, tablet or smartphone

A regiszter feltételei, szó szerint

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• 18 és 65 év között vagy?IgenNem

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The objective of this three-year study is to provide comprehensive care to young adults presenting with ARMS. The aim is use an exercise group (EGChat) developed by prior study and CES to decrease cognitive mental risks, improve emotional stability, enhance sleep quality, and elevate overall life satisfaction. A randomized controlled trial (RCT) design will be conducted using purposive sampling to recruit 180 young adults with ARMS from a medical center and its affiliated hospitals. Participants will be randomly assigned to one of three groups, undergoing a 16-week intervention: EGChat plus CES, EGChat without CES, or CES without EGChat groups. The study integrates the EGChat application into an online health promotion platform, coupled with CES intervention, to enhance the biological and psychological health of individuals at ARMS. The goal of this RCT study is to enhance the biological and psychological well-being of individuals with ARMS, covering exercise levels, Brain-Derived Neurotrophic Factor (BDNF) levels, health-promoting behaviors, metabolic indexes, cognitive mental risks, emotional status, sleep quality, and overall life quality. Assessments will occur at baseline (T0), 8 weeks into the intervention (T1), upon completion of the 16-week intervention (T2), and during a follow-up assessment at 3 months post-intervention (T3). The study will utilize generalized estimating equations (GEE) for mixed model repeated measures analysis to evaluate the significant influences of the intervention and interactions between study variables, utilizing group-time interaction.

A vizsgálat 3 csoportja

• Chatbot & CESA vizsgált kezelés

  Exercise Chatbot intervention with Cranial Electrical Stimulation intervention

  Kezelés: Both EGChat and CES intervention

• ChatbotA vizsgált kezelés

  Exercise Chatbot intervention without Cranial Electrical Stimulation intervention

  Kezelés: Exercise Chatbot

• CESA vizsgált kezelés

  Cranial Electrical Stimulation intervention without Exercise Chatbot intervention

  Kezelés: CES (Cranial Electrotherapy Stimulation)