Lifestyle Intervention to Reduce the Risk of Sarcopenia in Adults With Diabetes & Obesity Treated With Semaglutide

Ki vehet részt

• Patients 65 years and above
• Patients who were previously diagnosed with type 2 diabetes
• Overweight / obesity (body mass index, BMI ≥ 27 kg/m2)

Ki nem vehet részt

• Patients who are in active nutritional therapy
• Patients who changed their diet recently (< 1 month) and/or in a weight-loss program with >5% weight loss or used anti-obesity drugs in the last 3 months
• Patients who are currently using systemic steroids
• Patients with musculoskeletal disorders, which, by the judgment of the investigators, would limit their ability to perform the exercise training
• Patients with neurological diseases, which by the judgment of the investigators, would affect their ability to participate in the trial
• Patients with a history of amputation that impairs their ability to participate in the exercise program
• Patients with active oncological diseases, excluding non-melanoma skin cancer
• Patients with diagnosed dementia or cognitive impairment that, in the view of the researchers, may impair their ability to sign a consent form or participate in the trial
• Any contraindication to Magnetic resonance imaging (MRI) (e.g., MRI non-compatible cardiac implantable electronic device, metallic foreign bodies, implantable neurostimulation system, cochlear implants/ear implant, non-removable drug infusion pumps, catheters with metallic components, cerebral artery aneurysm clips which), or inability to perform an MRI scanner (e.g., claustrophobia)
• Patients with Estimated Glomerular Filtration Rate (eGFR)<30 ml/min/1.73 m2
• Patients with significant hearing or visual disability
• Patients who reported a weight loss of >5kg within 90 days of screening
• Patients who were on Glucagon-like peptide-1 receptor agonists (GLP-1-RA) treatment during the last 3 months
• Patients with disabilities, which, by the judgment of the investigators, would affect their ability to participate in the trial
• Patients who use a walking aid
• Patients who were hospitalized in the past month
• Patients who exercise regularly and in the eyes of the examiner will not benefit from the intervention program
• Anyone who is not suitable to participate in the study, according to the researcher's discretion
• Patients who do not fit within the measurement field of view of the Dual-energy X-ray absorptiometry (DXA) scanner in a supine position with the arms next to the body