Role of ET-1, Physical Activity, and Sedentary Behavior in Microvascular Dysfunction Following GDM

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• 18 és 50 év között vagy?IgenNem

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Women with a history of gestational diabetes mellitus (GDM) are at a 2-fold greater risk for the development of overt cardiovascular disease (CVD) following the effected pregnancy. While subsequent development of type II diabetes elevates this risk, prior GDM is an independent risk factor for CVD morbidity, particularly, within the first decade postpartum. GDM is associated with impaired endothelial function during pregnancy and decrements in macro- and microvascular function persist postpartum, despite the remission of insulin resistance following delivery. Collectively, while the association between GDM and elevated lifetime CVD risk is clear, and available evidence demonstrates a link between GDM and vascular dysfunction in the decade following pregnancy, the mechanisms mediating this persistent dysfunction remain unexamined.

A vizsgálat 4 csoportja

• local lactated Ringer's perfusionPlacebo, összehasonlításként

  lactated Ringer's is perfused through the microdialysis fiber to serve as the vehicle control

  Kezelés: Insulin aspart

• local BQ-788 and BQ-123 perfusionA vizsgált kezelés

  local ET-1 inhibitors perfused through the microdialysis fiber to serve as the experimental treatment

  Kezelés: Insulin aspart

• local L-NAME perfusionA vizsgált kezelés

  local L-NAME is perfused through the microdialysis fiber to inhibit nitric oxide synthase

  Kezelés: Insulin aspart

• local BQ-788 + BQ-123 + L-NAME perfusionA vizsgált kezelés

  local ET-1 inhibitors and L-NAME are perfused through the microdialysis fiber to inhibit nitric oxide synthase during the experimental treatment

  Kezelés: Insulin aspart