Does a Periaqueductal Gray-vagus Nerve Interface Malfunction Explain the Nat hx With Its Numerous Co-morbidities?

A vizsgálat adatai

Ki végzi

Virginia Commonwealth University

Azonosító

NCT06616363

A regiszteradat frissítve

2026. szeptember 29.

Eredeti leírás

Postural tachycardia syndrome (POTS) is a common and disabling disorder among adolescents. No epidemiologic data exist to support the often cited 0.5 to 2% prevalence. Case series suggest 3 to 5 times greater incidence in girls than boys. POTS is defined in children as daily chronic symptoms of orthostatic intolerance and a 40 bpm rise in heart rate in the first 10 minutes of a tilt study in the absence of orthostatic hypotension. POTS often develops after an acute event like an illness, infection, immunization, head trauma, psychological trauma or surgery. Natural history data are absent for POTS, though some outcome studies exist. Orthostatic symptoms improve in the majority and heart rate changes improve in 38% at 1 year. A 2-year follow up showed small improvement in comorbid symptoms of POTS in a 12 subject cohort followed yearly. In a pediatric 5-year outcome follow up questionnaire study, 86% of adolescents with POTS reported resolved, improved, or intermittent, symptoms, with primarily physical rather than mental health complaints.A teljes eredeti leírásKevesebb

(PAG POTS - NIH) Pediatric Postural Orthostatic Tachycardia Syndrome (POTS) : Does a Periaqueductal Gray-vagus Nerve Interface Malfunction Explain the Natural History With Its Numerous Co-morbidities?

Postural tachycardia syndrome (POTS) is a common and disabling disorder among adolescents. No epidemiologic data exist to support the often cited 0.5 to 2% prevalence. Case series suggest 3 to 5 times greater incidence in girls than boys. POTS is defined in children as daily chronic symptoms of orthostatic intolerance and a 40 bpm rise in heart rate in the first 10 minutes of a tilt study in the absence of orthostatic hypotension. POTS often develops after an acute event like an illness, infection, immunization, head trauma, psychological trauma or surgery. Natural history data are absent for POTS, though some outcome studies exist. Orthostatic symptoms improve in the majority and heart rate changes improve in 38% at 1 year. A 2-year follow up showed small improvement in comorbid symptoms of POTS in a 12 subject cohort followed yearly. In a pediatric 5-year outcome follow up questionnaire study, 86% of adolescents with POTS reported resolved, improved, or intermittent, symptoms, with primarily physical rather than mental health complaints.

Bevonási feltételek: symptomatic ≥ 40 bpm rise in heart rate in the first 10 min of a tilt table study without a drop in blood pressure; Clinical symptoms of orthostatic intolerance; acute upper respiratory or gastrointestinal infection that required admission to the acute care units but not requiring an ICU stay; Apparently healthy with no known chronic illnesses.

Kizáró feltételek: Other chronic diseases; Unstable medical conditions; Chronic prescriptions, history of POTS or orthostatic symptoms, recent inpatient psychiatric admissions, substance use disorder, trauma such as a motor vehicle accident, surgery, or other significant physical or emotional trauma in the last 5 years; Other unstable chronic diseases; Unstable medical conditions; History of POTS or orthostatic symptoms, migraines, fibromyalgia, chronic fatigue, PTSD. Functional gastrointestinal disorders, fainting, dysmenorrhea, or other chronic pain syndrome, inpatient psychiatric admissions, substance use disorder, trauma such as a motor vehicle accident, surgery, or other significant physical or emotional trauma in the last 5 years; Other chronic unstable diseases; Unstable medical conditions; A phone older than 5 years old or unable to support EMA software; POST INFECTION; A phone older than 5 years old or unable to support EMA software; HEALTHY CONTROLS; A phone older than 5 years old or unable to support EMA software; Pregnant or breastfeeding; Cognitive defects that preclude answering questionnaires or following assessment directions; Use of narcotics; Limited English proficiency; Investigator discretion that participant would not be suitable to participate; Pregnant or breastfeeding; Cognitive defects that preclude answering questionnaires or following assessment directions; Use of narcotics; Severe depression or anxiety (untreated / unstable); Limited English proficiency; Investigator discretion that participant would not be suitable to participate; Pregnant or breastfeeding; Cognitive defects that preclude answering questionnaires or following assessment directions; Use of narcotics; Severe depression or anxiety (untreated / unstable); Limited English proficiency; Investigator discretion that participant would not be suitable to participate.

POTS sample.

ClinicalTrials.gov NCT06616363