Development of a Cognitive Tool for Rapid and Reliable Screening of Minimal Hepatic Encephalopathy: Pilot Study

MI-összefoglaló

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The trial is looking for adults with a liver disease (fibrosis, cirrhosis or porto-systemic shunts) to test a new thinking-skills test using building blocks.

Életkor

18 to 70 years

Nem

All sexes

A betegség stádiuma

Liver disease: fibrosis (scarring), cirrhosis, or porto-systemic shunts (abnormal blood vessel links that bypass the liver).

A részvétel fő kizáró okai

• People who object to taking part cannot join.
• People not covered by the French healthcare system cannot join.
• People not assessed at the BLIPS clinic (brain tests, MRI, EEG and a blood test with ammonia) cannot join.

A regiszter feltételei, szó szerint

Nézd meg, megfelelhetsz-e

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• 18 és 70 év között vagy?IgenNem

Mit akar kideríteni a vizsgálat

The aim of this project is to evaluate the sensitivity and specificity of a cognitive test toward the presence of minimal hepatic encephalopathy (MHE). MHE is a neurological complication due to hepatic dysfunction and/or the presence of porto-systemic shunts defined by the presence of neurocognitive impairments (NI). Other factors of brain injury may cause NI independently from the liver condition making the differential diagnosis difficult using available cognitive tests (ANT Animal Naming Test, PHES Psychometric Hepatic Encephalopathy Score, CFF Critical Flicker Frequency test). The cognitive test evaluated in this project is a construction task using construction blocks, allowing the evaluation of psychomotor speed, executive functions, attention, and episodic memory. The measures will be compared to other cognitive tests validated for the evaluation of the targeted cognitive functions (PHES, Mesulam Cancelling task, Rey-Osterrieth complex figure, Free and Cued Selective Reminding Test) and cognitive tests validated for the diagnosis of MHE (PHES, ANT, CFF). The diagnosis of MHE is based on an adjudication committee including a multimodal assessment of MHE (brain MRI with spectroscopy, EEG, blood sample, neuropsychological assessment), allowing the evaluation of comorbidities such as other factors of brain injury.

A vizsgálat csoportja

• Patients

  Population with chronic liver disease or the presence of portal-systemic shunts, attending the BLIPS day hospital

  Kezelés: Cognitive test