Trazodone on NREM Sleep Stage Ⅲ in Depressed Insomniac Co-morbid Patients

Ki vehet részt

• Outpatient or inpatient patients
• 18 years old ≤ 65 years old
• Simultaneously meet the diagnostic criteria for depression and non organic insomnia in the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) in the United States
• 17 items of Hamilton Depression Rating Scale (HAMD-17) with a total score of ≥ 17 points
• Pittsburgh Sleep Quality Index (PSQI) ≥ 16 points
• Never used related antidepressants and sedative hypnotic drugs
• Has a certain level of visual and auditory resolution, and no comprehension barriers
• Capable of independently completing scale measurements
• Education level above primary school
• Obtain written informed consent from the patient, and obtain written informed consent from the legal guardian if the patient is incapacitated during the onset of the illness

Ki nem vehet részt

• Positive for syphilis specific antibody and AIDS antibody
• Patients with comorbidities such as schizophrenia, schizophrenia, bipolar disorder, mental retardation, pervasive developmental disorder, delirium, dementia, cognitive impairment, alcohol dependence, etc
• Suffering from serious organic diseases, such as diabetes, thyroid disease, hypertension, cardiovascular disease, craniocerebral trauma, cerebral ischemia or hemorrhage
• History of epilepsy and febrile seizures
• Individuals with a history of drug use
• Laboratory tests indicate the presence of liver and kidney function impairment in individuals
• Patients with narrow angle glaucoma
• According to risk assessment, there are currently serious suicide attempts or individuals who are overly agitated Pregnant or lactating women, or those planning to conceive in the near future
• There are other individuals who meet the relevant contraindications for antidepressants