A Study Evaluating the Efficacy and Safety of Divarasib and Pembrolizumab Versus Pembrolizumab and Pemetrexed and Carboplatin or Cisplatin in Participants With Previously Untreated, KRAS G12C-Mutated, Advanced or Metastatic Non-Squamous Non-Small Cell Lung Cancer

A vizsgálat adatai

Ki végzi

Hoffmann-La Roche

Azonosító

NCT06793215

A regiszteradat frissítve

2026. november 5.

Eredeti leírás

The purpose of this study is to evaluate the efficacy and safety of divarasib and pembrolizumab compared with pembrolizumab and pemetrexed and carboplatin or cisplatin, for the first-line treatment of adult participants with KRAS G12C-mutated, advanced or metastatic non squamous non-small cell lung cancer (NSCLC).A teljes eredeti leírásKevesebb

A Phase III, Randomized, Open-Label Study Evaluating the Efficacy and Safety of Divarasib and Pembrolizumab Versus Pembrolizumab and Pemetrexed and Carboplatin or Cisplatin in Patients With Previously Untreated, KRAS G12C-Mutated, Advanced or Metastatic Non-Squamous Non-Small Cell Lung Cancer

The purpose of this study is to evaluate the efficacy and safety of divarasib and pembrolizumab compared with pembrolizumab and pemetrexed and carboplatin or cisplatin, for the first-line treatment of adult participants with KRAS G12C-mutated, advanced or metastatic non squamous non-small cell lung cancer (NSCLC).

Bevonási feltételek: Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1; Histologically or cytologically confirmed diagnosis of advanced or metastatic non squamous NSCLC that is not eligible for curative surgery and/or definitive chemoradiotherapy; Measurable disease, as defined by RECIST v1.1; No prior systemic treatment for advanced or metastatic NSCLC; Documentation of the presence of a KRAS G12C mutation; Documentation of known PD-L1 expression status in tumor tissue; Availability of a representative tumor specimen; Adequate end-organ function; Eligible to receive a platinum-based chemotherapy regimen.

Kizáró feltételek: Known concomitant second oncogenic driver with available targeted treatment; Spinal cord compression not definitively treated with surgery and/or radiation or previously diagnosed and treated spinal cord compression without evidence that disease has been clinically stable for >=2 weeks prior to randomization; Any anti-cancer systemic therapy, including hormonal therapy, within 21 days prior to randomization, or is expected to require any other form of antineoplastic therapy while in the study; Radiation therapy including palliative RT to bone metastases within 2 weeks prior to randomization and RT to the lung >30Gy within 6 months prior to randomization; Prior treatment with KRAS G12C inhibitors or pan-KRAS/RAS inhibitors; Treatment with systemic immunosuppressive or immunostimulatory medications, including CD137 agonists and immune checkpoint inhibitors; Treatment with therapeutic oral or IV antibiotics within 2 weeks prior to randomization; Prior allogeneic stem cell or solid organ transplantation; Significant cardiovascular disease within 3 months prior to screening; History of leptomeningeal disease; History of malignancy other than NSCLC within 5 years prior to screening, with the exception of malignancies with a negligible risk of metastasis or death (e.g., 5-year overall survival [OS] rate >90%), such as adequately treated carcinoma in situ of the cervix, non melanoma skin carcinoma, localized prostate cancer, ductal breast carcinoma in situ, or Stage I uterine cancer; Individuals with chronic diarrhea, short bowel syndrome or significant upper gastrointestinal surgery including gastric resection, a history of inflammatory bowel disease (e.g., Crohn's disease or ulcerative colitis) or any active bowel inflammation (including diverticulitis), malabsorption syndrome, conditions that would interfere with enteral absorption; History of idiopathic pulmonary fibrosis, organizing pneumonia (e.g., bronchiolitis obliterans), drug-induced pneumonitis, or idiopathic pneumonitis, or evidence of active pneumonitis on the screening chest computed tomography scan; Current treatment with medications that are well known to prolong the QT interval; Symptomatic, untreated, or actively progressing central nervous system (CNS) metastases; Uncontrolled tumor-related pain; Uncontrolled pleural effusion, pericardial effusion, or ascites requiring recurrent drainage procedures (once a month or more frequently).

ClinicalTrials.gov NCT06793215