PET Imaging of Phosphodiesterase-4B (PDE4B) in Alcohol Use Disorder

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• Participants who have taken antidepressants or antipsychotic medications in the week prior or during their hospital admission
• Have recent exposure to radiation related to research (e.g., PET from other research) that, when combined with this study, would be above the allowable limits
• Participants who have an unstable medical condition that, in the opinion of the investigators, makes participation unsafe (e.g., an active infection or untreated malignancy)
• HIV infection
• Are unable to have an MRI scan (e.g., because of pacemakers or other implanted electrical devices, brain stimulators, dental implants, aneurysm clips (metal clips on the wall of a large artery), metallic prostheses (including metal pins and rods, heart valves, and cochlear implants), permanent eyeliner, implanted delivery pumps, shrapnel fragments, or metal fragments in the eye
• Clinically significant abnormalities on laboratory testing beyond that expected in participants during alcohol withdrawal. This includes CBC and acute care panel (Na, K, Cl, CO2, creatinine, glucose, urea nitrogen)
• Clinically significant abnormalities on EKG
• Participants who, in the investigator s judgment, pose a current serious suicidal or homicidal risk
• Participants with a breath alcohol level (BAL) past 0.08
• Pregnancy
• Have an inability to lie flat and/or lie still on the camera bed for two hours, including claustrophobia, overweight greater than the maximum for the scanner, and uncontrollable behavioral symptoms, which will be screened by an interview with the participant during the screening visit

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• INCLUSION CRITERIA:; Age 18-70 years; Willingness to complete the study including MRI tests; Each participant must have a level of understanding sufficient to agree to all required tests and examinations and sign an informed consent document; Participants must have their radial artery pulse checked for the presence of adequate ulnar collateral flow and the absence of any metal or foreign objects in both wrists; Participants must agree to adhere to the lifestyle considerations; Enrolled in protocol 14-AA-0181