Tumors and Respiratory System Diseases Due to Air Pollution: New Biomarkers of Exposure and Effects
A legfontosabb adatok
- Hol
- Bologna és Foggia (Olaszország)Mind a 3 helyszín megnézése
AI-kivonat: kiket keres a vizsgálat
A vizsgálat saját részvételi feltételeiből. Gép olvasta ki az oldalon álló regiszterszövegből, ezért tévedhet. Hogy ki vehet részt, azt a lenti regiszterszöveg és a vizsgálat csapata dönti el.
A vizsgálat olyan felnőtteket keres, akik még soha nem dohányoztak, és COPD-jük, tüdőrákjuk vagy leukémiájuk van. Emellett a vizsgálatot végző kórházakban dolgozó, egészséges, nem dohányzó önkénteseket is keres.
- Életkor
- 18 év vagy idősebb
- Nem
- Minden nem részt vehet
- A betegség stádiuma
- Bármilyen súlyosságú COPD, bármilyen típusú és stádiumú tüdőrák, vagy bármilyen típusú leukémia
- Korábbi kezelés
- A tüdőrákos résztvevők korábban nem kaphattak daganatellenes gyógyszeres kezelést. A leukémiás résztvevők korábban nem kaphattak daganatellenes kezelést, például alkilálószereket, hidroxiureát, topoizomeráz II-gátlókat vagy lenalidomidot.
- Biomarker vagy leletérték
- A COPD-t a hörgőtágítós vizsgálat utáni 0,7 alatti FEV1/FVC érték mutatja
A részvétel fő kizáró okai
- Élete során legalább 100 cigarettát elszívott, vagy jelenleg dohányzik
- COPD-csoport: alfa-1 antitripszin hiány
- Tüdőrákos csoport: korábbi vagy jelenlegi szolid daganat, mielodiszplasztikus szindróma vagy mieloproliferatív daganat
- Leukémiás csoport: genetikai állapotok, például Fanconi-anaemia vagy Down-szindróma, illetve HIV-, HTLV-1/2- vagy Epstein–Barr-vírus-fertőzés
- Egészséges önkéntesek: a kórelőzményükben COPD, szolid daganat vagy leukémia szerepel, vagy abban az osztályon dolgoznak, amelyik toborozza őket
Gépi kiolvasás: 2026. november 12.
Helyszínek itt: Olaszország
- Medical Oncology, IRCCS Azienda Ospedaliero-Universitaria di BolognaBologna, OlaszországContact: Andrea Ardizzoni, MDRésztvevőt keres
- Respiratory and Critical Care Unit, IRCCS Azienda Ospedaliera-Universitaria di BolognaBologna, OlaszországContact: Stefano Nava, MDRésztvevőt keres
- Ematology Unit, Azienda Ospedaliero-Universitaria, Policlinico Riuniti di FoggiaFoggia, OlaszországContact: Francesco Bellanti, MDRésztvevőt keres
Kérdések a vizsgálat csapatának
- Milyen gyakran kell bejárnom, és egy-egy alkalom mennyi ideig tart?
- Megtérítik az utazási költséget?
- Megtarthatom a saját orvosomat?
- Mi történik, ha ki akarok lépni?
Contact the study team: see the registry record → Contacts and Locations
Oldal nyomtatása az orvosomnakA vizsgálat adatai
- Ki végzi
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
- Azonosító
- NCT06800586
- A regiszteradat frissítve
- 2025. december 19.
- Eredeti leírás
This study aims to examine the exposure to atmospheric pollutants in a group of non-smoking patients suffering from lung cancer, chronic obstructive pulmonary disease (COPD), and leukemia. The exposure to atmospheric pollutants will be assessed simultaneously in a group of healthy volunteers. The ultimate goal of the study is to enhance the understanding of the mechanisms by which atmospheric pollutants act, in order to develop new tools that can help halt or at least delay the development of diseases associated with pollution.A teljes eredeti leírásKevesebb
This study aims to examine the exposure to atmospheric pollutants in a group of non-smoking patients suffering from lung cancer, chronic obstructive pulmonary disease (COPD), and leukemia. The exposure to atmospheric pollutants will be assessed simultaneously in a group of healthy volunteers. The ultimate goal of the study is to enhance the understanding of the mechanisms by which atmospheric pollutants act, in order to develop new tools that can help halt or at least delay the development of diseases associated with pollution.
Bevonási feltételek: Patient Cohort to be Recruited at the Department of Pneumology and Respiratory Intensive Care, IRCCS AOU of Bologna:; Age ≥ 18 years; Patients with a diagnosis of COPD of any severity (FEV1/FVC < 0.7 after bronchodilation test); Non-smokers according to ISS definition: patients who declare having smoked less than 100 cigarettes (5 packs of 20) in their lifetime and are not currently smokers; Signature of informed consent; Healthy Volunteer Cohort to be Recruited at the Department of Pneumology and Respiratory Intensive Care, IRCCS AOU of Bologna:; Age ≥ 18 years; Non-smokers according to ISS definition: subjects who declare having smoked less than 100 cigarettes (5 packs of 20) in their lifetime and are not currently smokers; Absence of comorbidities related to the study (COPD, solid tumors, leukemia) in medical history; Workers of the IRCCS AOU of Bologna, S. Orsola Polyclinic; Signature of informed consent; Patient Cohort to be Recruited at the Department of Medical Oncology, IRCCS AOU of Bologna:; Age ≥ 18 years; Patients with a diagnosis of lung neoplasm of any histotype and stage; Non-smokers according to ISS definition: patients who declare having smoked less than 100 cigarettes (5 packs of 20) in their lifetime and are not currently smokers; Signature of informed consent; Healthy Volunteer Cohort to be Recruited at the Department of Medical Oncology, IRCCS AOU of Bologna:; Age ≥ 18 years; Non-smokers according to ISS definition: subjects who declare having smoked less than 100 cigarettes (5 packs of 20) in their lifetime and are not currently smokers; Absence of comorbidities related to the study (COPD, solid tumors, leukemia) in medical history; Workers of the IRCCS AOU of Bologna, S. Orsola Polyclinic; Signature of informed consent; Patient Cohort to be Recruited at the Hematology Department (Hospital-University Company, Policlinico Riuniti di Foggia):; Age ≥ 18 years; Non-smokers according to ISS definition: patients who declare having smoked less than 100 cigarettes (5 packs of 20) in their lifetime and are not currently smokers; Patients with a diagnosis of leukemia of any type; Signature of informed consent; Healthy Volunteer Cohort to be Recruited at the Hematology Department (Hospital-University Company, Policlinico Riuniti di Foggia):; Age ≥ 18 years; Non-smokers according to ISS definition: subjects who declare having smoked less than 100 cigarettes (5 packs of 20) in their lifetime and are not currently smokers; Absence of comorbidities related to the study (COPD, solid tumors, leukemia) in medical history; Workers of the Hospital-University Company, Policlinico Riuniti di Foggia; Signature of informed consent.
Kizáró feltételek: Previous and/or current diagnosis of solid tumors, myelodysplastic syndromes, myeloproliferative neoplasms; Previous and/or current treatment with antineoplastic agents; Healthy Volunteer Cohort to be Recruited at the Department of Medical Oncology, IRCCS AOU of Bologna:; Previous diagnosis of solid tumors, myelodysplastic syndromes, myeloproliferative neoplasms; Previous treatment with antineoplastic agents (alkylating agents, hydroxyurea, topoisomerase II inhibitors, lenalidomide) -Presence of pre-existing genetic conditions (Fanconi anemia, ataxia- telangiectasia, Down syndrome, xeroderma pigmentosum, Li-Fraumeni syndrome); Infection with human immunodeficiency virus (HIV), human T-lymphotropic virus types 1 or 2, or Epstein-Barr virus; Healthy Volunteer Cohort to be Recruited at the Hematology Department (Hospital-University Company, Policlinico Riuniti di Foggia):; Patient Cohort to be Recruited at the Department of Pneumology and Respiratory Intensive Care, IRCCS AOU of Bologna:; Deficiency of alpha-1 antitrypsin (A1AT); Healthy Volunteer Cohort to be Recruited at the Department of Pneumology and Respiratory Intensive Care, IRCCS AOU of Bologna:; Workers from the Department of Pneumology and Respiratory Intensive Care, IRCCS AOU of Bologna, S. Orsola Polyclinic; Patient Cohort to be Recruited at the Department of Medical Oncology, IRCCS AOU of Bologna:; Workers from the Department of Medical Oncology, IRCCS AOU of Bologna, S. Orsola Polyclinic; Patient Cohort to be Recruited at the Hematology Department (Hospital-University Company, Policlinico Riuniti di Foggia):; Workers from the Hematology Department, Hospital-University Company, Policlinico Riuniti di Foggia.