Insomnia´s Impact on DNA Stability, Cardio-metabolic Health and Lifestyle Behaviors

MI-összefoglaló

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The trial is looking for adults in five groups: healthy young adults, athletes, older adults, university students and people with metabolic syndrome. It studies how insomnia affects body, fitness, metabolism and DNA.

Életkor

18 to 75 years. Healthy adults, athletes, students and people with metabolic syndrome: 18-35 years. Older adults: 65-75 years.

Nem

Men and women can join.

A betegség stádiuma

Healthy group: waist <90 cm (35 in) (men), <80 cm (31 in) (women), fasting glucose 70-110 mg/dL (3,9–6,1 mmol/L), blood pressure <120/80 mmHg, triglycerides <150 mg/dL (1,7 mmol/L), HDL-C >40 mg/dL (1 mmol/L) (men), >50 mg/dL (1,3 mmol/L) (women), activity 600-1500 MET-min/week. Athletes: structured sports training, activity >1500 MET-min/week. Older adults: no cognitive or mental health disorders. Metabolic syndrome group: waist >90 cm (35 in) (men), >80 cm (31 in) (women), fasting glucose >110 mg/dL (6,1 mmol/L), blood pressure >130/80 mmHg, triglycerides >150 mg/dL (1,7 mmol/L), HDL-C <40 mg/dL (1 mmol/L) (men), <50 mg/dL (1,3 mmol/L) (women), activity <600 MET-min/week.

A részvétel fő kizáró okai

• Lung or breathing diseases that prevent exercise
• Muscle, bone or joint injuries that prevent exercise
• Rotating or night-shift work
• Women with polycystic ovary syndrome (PCOS)
• Women with high testosterone and a history of rare or light periods (oligomenorrhea)

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• 18 és 75 év között vagy?IgenNem

Mit akar kideríteni a vizsgálat

Insomnia is a highly prevalent sleep disorder worldwide, with an increasing incidence in athletes, older adults, university students, and individuals with metabolic syndrome. This disorder has been associated with metabolic dysfunction, cardiovascular diseases, and genetic instability. Recent evidence suggests that insomnia negatively impacts cardiorespiratory fitness, insulin sensitivity, and overall health through mechanisms involving neuroendocrine dysregulation, oxidative stress, and alterations in energy metabolism. However, the specific biological and environmental factors that contribute to its prevalence and health consequences remain poorly understood, particularly across different populations. Understanding these associations is crucial for developing effective prevention and intervention strategies to mitigate the long-term impact of insomnia. Therefore, this study aims to analyze the impact of insomnia on body composition, cardiorespiratory fitness, metabolic flexibility, and DNA integrity, across populations with high prevalence of insomnia, including athletes, older adults, university students, and individuals with metabolic syndrome. This study will also investigate which biological and lifestyle behaviors contribute to insomnia and its health consequences. By doing so, this work will provide critical insights into the physiological and molecular mechanisms that link insomnia with metabolic and cardiovascular dysfunction, contributing to the development of targeted interventions for at-risk populations

A vizsgálat 5 csoportja

• Healthy young adults

  This group consists of individuals aged 18-35 with no prior diagnosis of insomnia, sleep disorders, or chronic metabolic conditions. Body composition, cardiorespiratory fitness, lifestyle behaviors, DNA integrity and metabolic flexibility will be examined in all participants.

  Kezelés: Exercise, Bioelectrical Impedance, Micronucleus Assay, Physical activity and sedentary time, Sleep, blood sampling, psychometrics, Nutritional Supplement és Genotyping

• College Students

  University students aged 18-35 years, with current affiliation to the Universidad Autonoma de Baja California. Body composition, cardiorespiratory fitness, lifestyle behaviors, DNA integrity and metabolic flexibility will be examined in all participants.

  Kezelés: Exercise, Bioelectrical Impedance, Micronucleus Assay, Physical activity and sedentary time, Sleep, psychometrics, Nutritional Supplement és Genotyping

• Athletes

  Amateur and professional athletes with 2 years of training and competitive experience. Body composition, cardiorespiratory fitness, lifestyle behaviors, DNA integrity and metabolic flexibility will be examined in all participants.

  Kezelés: Exercise, Bioelectrical Impedance, Micronucleus Assay, Physical activity and sedentary time, Sleep, blood sampling, psychometrics, Nutritional Supplement és Genotyping

• Elders

  Older adults (65-75 years) without a medical history of cognitive disorders or mental health issues. Body composition, cardiorespiratory fitness, lifestyle behaviors, DNA integrity and metabolic flexibility will be examined in all participants.

  Kezelés: Exercise, Bioelectrical Impedance, Micronucleus Assay, Physical activity and sedentary time, Sleep, blood sampling, psychometrics, Nutritional Supplement és Genotyping

• Metabolic syndrome

  Individuals aged 18-35 with previous diagnosis of metabolic syndrome. Body composition, cardiorespiratory fitness, lifestyle behaviors, DNA integrity and metabolic flexibility will be examined in all participants.

  Kezelés: Exercise, Bioelectrical Impedance, Micronucleus Assay, Physical activity and sedentary time, Sleep, blood sampling, psychometrics, Nutritional Supplement és Genotyping