Butyric Acid Supplementation for Gut Improvement After Cardiac Surgery in Kids
A legfontosabb adatok
- Hol
- Omaha (Egyesült Államok)A helyszín megnézése
- Fázis
- 1/2. fázis
Helyszínek itt: Egyesült Államok
- Children's Nebraska, 8200 Dodge StOmaha, Egyesült ÁllamokContact: Jeffrey D Salomon, MDRésztvevőt keres
Kérdések a vizsgálat csapatának
- Milyen gyakran kell bejárnom, és egy-egy alkalom mennyi ideig tart?
- Megtérítik az utazási költséget?
- Megtarthatom a saját orvosomat?
- Mi történik, ha ki akarok lépni?
Contact the study team: see the registry record → Contacts and Locations
Oldal nyomtatása az orvosomnakA vizsgálat adatai
- Ki végzi
- University of Nebraska
- Azonosító
- NCT06882772
- A regiszteradat frissítve
- 2026. október 30.
- Eredeti leírás
Butyric acid has been shown to promote gut health and improve the microbiome in multiple adult studies. In preliminary studies in older children with inflammatory bowel disease, butyric acid was shown to be safe. However, it's suitability for infants and young children with congenital heart disease (CHD) has yet to be determined.A teljes eredeti leírásKevesebb
Butyric Acid Supplementation for Gut Improvement After Cardiac Surgery in Kids, A Phase IIa Clinical Trial
Butyric acid has been shown to promote gut health and improve the microbiome in multiple adult studies. In preliminary studies in older children with inflammatory bowel disease, butyric acid was shown to be safe. However, it's suitability for infants and young children with congenital heart disease (CHD) has yet to be determined.
This study will examine butyric acid supplementation in infants and children, ages 1 month to 3 years, with CHD who require cardiac surgery with cardiopulmonary bypass. Study goals include determining the safety and tolerability of butyric acid supplementation before cardiac surgery, and to identify changes in gut microbial communities, metabolic profile, and genetic markers intestinal function. Also, the study seeks to establish a reduction in inflammation (inflammatory signaling) after cardiopulmonary bypass (CPB) in participants receiving butyric acid.
Bevonási feltételek: Infants and Children undergoing cardiac surgery with cardiopulmonary bypass.
Kizáró feltételek: Antibiotics, surgery, or chemotherapy within the past 8 weeks; Continuous enteral feeds before surgery; GI pathology or intestinal surgery (excluding G-tube); Liver disease with elevated transaminitis or dialysis-dependent renal disease.