Anti-phospolipid Antibodies in Lyme Borreliosis

MI-összefoglaló

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The trial is looking for adults with Lyme borreliosis, a disease spread by tick bites. It also includes people with nonspecific symptoms and Borrelia antibodies in the blood, and healthy blood donors. Researchers will measure anti-phospholipid antibodies in blood samples.

Életkor

18 Years and older

Nem

All sexes

A betegség stádiuma

Lyme borreliosis that meets the European clinical case definition. Forms include solitary or multiple erythema migrans (skin rash), Lyme neuroborreliosis (nerves), Lyme arthritis (joints) and acrodermatitis chronica atrophicans (long-term skin form). There is also a group with nonspecific symptoms.

Korábbi kezelés

The first blood sample is taken before antibiotic treatment.

Biomarker vagy leletérték

For the nonspecific symptoms group: positive Borrelia antibodies in the blood serum.

A részvétel fő kizáró okai

• Autoimmune diseases
• Acute heart attack (myocardial infarction)
• Acute deep vein thrombosis (blood clot in a deep vein)
• Pregnancy
• Syphilis

A regiszter feltételei, szó szerint

Mit akar kideríteni a vizsgálat

Background Lyme borreliosis, caused by Borrelia burgdorferi sensu lato is transmitted to humans through the bite of an infected Ixodes tick. B. burgdorferi sensu lato accumulates intact phospholipids from its environment to support its growth. Several of these environmentally acquired phospholipids including phosphatidylserine, phosphatidylcholine and phosphatidic acid may be recognized by anti-phospholipid antibodies that are believed to arose early in infection. Here we aimed to investigate the levels of anti-phospholipid antibodies in patients with Lyme borreliosis.

A vizsgálat 3 csoportja

• Patients with different well-defined manifestations of Lyme borreliosis

  150 patients with well-defined Lyme borreliosis of which: 30 presented with solitary erythema migrans (EM), 30 with multiple EM (MEM), 30 with Lyme neuroborreliosis (LNB), 30 with Lyme arthritis (LA), 30 with acrodermatitis chronica atrophicans (ACA).

  Kezelés: Anti-phospholipid antibodies

• Patients with nonspecific symptoms and positive borrelial antibodies in serum.

  50 patients with nonspecific symptoms and positive borrelial antibodies in serum.

  Kezelés: Anti-phospholipid antibodies

• Blood donors

  40 healthy blood donors.

  Kezelés: Anti-phospholipid antibodies