Comparing the Efficacy of Lyophilized Self Growth Factor Versus PRP Injection for Knee OA

MI-összefoglaló

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The trial is looking for adults with mild to moderate knee osteoarthritis and knee pain. It compares knee injections of a freeze-dried growth factor made from your own blood, PRP and salt water.

Életkor

Over 20 and under 80 years (record lists 20 Years to 80 Years).

Nem

Men and women can join.

A betegség stádiuma

Osteoarthritis in one or both knees, with symptoms for more than 3 months. X-ray shows mild to moderate disease (Kellgren-Lawrence grades 1-3). Knee pain score (VAS) greater than 4.

Korábbi kezelés

No hyaluronic acid or corticosteroid injections into the joint in the past six months. No NSAIDs or oral corticosteroids within 7 days before treatment. No joint replacement or major surgery on the treated knee.

A részvétel fő kizáró okai

• Severe knee osteoarthritis (Kellgren-Lawrence grade 4), or severe knee deformity or instability.
• Current body-wide infection, or history of HIV/AIDS, syphilis or other notifiable infectious diseases.
• History of cancer, rheumatoid arthritis, platelet problems, low platelets, low fibrinogen, chronic liver disease, or poorly controlled heart disease or diabetes.
• Currently taking blood thinners, or long-term or heavy use of aspirin or vitamin E.
• Pregnant or breastfeeding, or unable to use effective birth control during treatment.

A regiszter feltételei, szó szerint

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• 20 és 80 év között vagy?IgenNem

Mit akar kideríteni a vizsgálat

Knee osteoarthritis(OA) is a common degenerative joint disease that often leads to knee pain, stiffness, and a decline in quality of life among middle-aged and elderly individuals. Platelet-rich plasma (PRP) is a regenerative treatment method that involves drawing a small amount of the patient's own blood and using centrifugation process to produce PRP. PRP, which is rich in growth factors and anti-inflammatory cytokines, facilitate the repair of damaged tissues and has been used in treating knee OA. Self-repair factor (SRF), an advanced form of PRP, is created using multi-step centrifugation and proprietary processes to increase platelet concentration. This enhancement may offer superior repair efficacy and faster recovery compared to traditional PRP. To explore this potential, we designed a randomized, double-blind, clinical trial to compare the effectiveness of SRF and PRP in treating degenerative knee osteoarthritis.

A vizsgálat 3 csoportja

• Lyophilized self growth factorA vizsgált kezelés

  Knee Intraarticular injection with Lyophilized self growth factor

• Platelet-Rich Plasma(PRP)Már használt kezelés, összehasonlításként

  Knee intraarticular injection with Platelet-Rich Plasma(PRP)

• normal salinePlacebo, összehasonlításként

  Knee intraarticular injection with normal saline

  Kezelés: Placebo