Development of Computational Models to Predict the Short-, Medium- and Long-term Cartilage Degeneration and Pain for Patients With Early-stage Osteoarthritis or Anterior Cruciate Ligament Injury

Egyéb feltételek

• .3.1 ACL reconstruction group (n= 25) Inclusion criteria
• Adults under 70 years
• ACL injury within the last year and planned for ACL reconstruction at inclusion
• Informed consent form signed Exclusion criteria (at inclusion)
• Previous knee surgery before current knee trauma
• Severe ischemic or neurological sequelae
• BMI above 32
• Clinically significant joint disease (inflammatory or degenerative) to other joints than the ACL injured knee (according to the clinician)
• Unsuitable for MRI (e.g. pacemaker or claustrophobia)
• Participants not able to fit the MRI knee coil (Thigh circumference larger than 73.5 cm measured 10 cm above the kneecap and a maximum calf circumferences of 61.5 cm)
• Drug addiction defined as the use of cannabis, opioids or other drugs as reported by the participant; ACL no reconstruction group (n= 25) Inclusion criteria
• Adults under 70 years
• ACL injury within the last year and with no plans for ACL reconstruction at inclusion
• Informed consent form signed Exclusion criteria (at inclusion)
• Previous knee surgery before current knee trauma
• Severe ischemic or neurological sequelae
• BMI above 32
• Clinically significant joint disease (inflammatory or degenerative) to other joints than the ACL injured knee (according to the clinician)
• Unsuitable for MRI (e.g. pacemaker or claustrophobia)
• Participants not able to fit the MRI knee coil (Thigh circumference larger than 73.5 cm measured 10 cm above the kneecap and a maximum calf circumferences of 61.5 cm)
• Drug addiction defined as the use of cannabis, opioids or other drugs as reported by the participant; Early to moderate knee OA stage (n= 25) Inclusion criteria
• Adults under 70 years
• Diagnosis of knee OA (Kellgren Lawrence (KL) grade 1, 2 and 3 (Kohn et al., 2016). If there is no X-ray that is a maximum of 1 year old, a new one is taken
• Stress-related pain in the knee and knee stiffness
• Informed consent form signed Exclusion criteria (at inclusion)
• Previous knee surgery
• Clinically significant joint disease (inflammatory or degenerative) of other joints than the knee at inclusion
• Severe ischemic or neurological sequelae in the lower extremities
• Clinically significant joint disease (inflammatory or degenerative) to other joints than the knees (according to the clinician)
• BMI above 32
• Unsuitable for MRI (e.g., pacemaker or claustrophobia)
• Participants not able to fit the MRI knee coil (Thigh circumference larger than 73.5 cm measured 10 cm above the kneecap and a maximum calf circumferences of 61.5 cm)
• Drug addiction defined as the use of cannabis, opioids or other drugs as reported by the participant; Control groups (3 groups of 10 control participants matched for each of the patient groups, n=30) Inclusion criteria
• Adults under 70 years
• Informed consent form signed
• No radiological changes on a knee x-ray (Arendt-Nielsen et al., 2015). Exclusion criteria (at inclusion)
• Previous knee surgery
• Self-reported Knee problems (pain, stiffness)
• Clinically significant joint disease (inflammatory or degenerative) at inclusion
• Severe ischemic or neurological sequelae in the lower extremities
• BMI above 32
• Unsuitable for MRI (e.g., pacemaker or claustrophobia)
• Participants not able to fit the MRI knee coil (Thigh circumference larger than 34.3-73.5 cm measured 10 cm above the kneecap and a maximum calf circumferences of 61.5 cm)
• Drug addiction defined as the use of cannabis, opioids, or other drugs as reported by the participant