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Cognitive-Motor Incorporated Training and Its Relations in Cerebrovascular Diseases With Cognitive and Motor Impairments

A legfontosabb adatok

Ki végzi
National Taiwan University Hospital
Hol
Taipei (Tajvan)A helyszín megnézése
Azonosító
Állapot
Toboroz
Résztvevők
210 fő, tervezett
Kezdés
2025. jún. 23.
Várható befejezés
2028. aug. 31.
A vizsgálat típusa
Beavatkozással járó, 7 csoportAz egyik csoport egy már használt kezelést kap, összehasonlításként.
A vizsgált kezelések
  • MCIT program
  • Motor training program
A regiszteradat frissítve
2026. augusztus 28.

Ki vehet részt

MI-összefoglaló

A vizsgálat saját részvételi feltételeiből. Gép olvasta ki az oldalon álló regiszterszövegből, ezért tévedhet. Hogy ki vehet részt, azt a lenti regiszterszöveg és a vizsgálat csapata dönti el.

A vizsgálat olyan felnőtteket keres, akiknek stroke után gondolkodási nehézségeik vannak, vagy Moyamoya-betegségük van. Egészséges felnőttek is részt vehetnek az egyik részben összehasonlításként.

Életkor
20 és 100 év között
Nem
Mindkét nem
A betegség stádiuma
Agyi CT-vel vagy MRI-vel igazolt stroke, amelynek tünetei több mint 7 napja kezdődtek. Vagy CT-vel vagy angiográfiával igazolt Moyamoya-betegség vagy -szindróma; ha stroke történt, annak legalább egy hete kell lennie.
Biomarker vagy leletérték
A gondolkodást mérő teszt (MoCA) pontszáma 26 alatt van a stroke-os vagy Moyamoya-betegeknél. Az egészséges kontrollszemélyeknél a MoCA pontszám 26 feletti.

A részvétel fő kizáró okai

  • Instabil vagy rosszul beállított életjelek, például szívritmus, légzésszám, oxigénszint vagy vérnyomás
  • Invazív gépi lélegeztetés szükségessége, vagy az orvos instabil egészségi állapotot állapít meg
  • Más agyi vagy idegrendszeri betegség, amely zavarhatja a vizsgálatot
  • Jelenleg intenzív osztályon van
  • Súlyos látás- vagy hallásprobléma, vagy kommunikációs, értési nehézség

A regiszter feltételei, szó szerint

Mind a 28 feltétel megnézéseKevesebb

Ki vehet részt

  • For aged-matched healthy controls:; being 20 years of age or older; the ability to stand for more than 30 seconds; a MoCA score of higher than 26
  • For PSCI participants:; Diagnosis of stroke confirmed by brain CT or MRI, with symptom onset more than 7 days prior (subacute or chronic phase); Being 20 years of age or older; The ability to stand for more than 30 seconds; a MoCA score of less than 26
  • For the MMD group:; a confirmed diagnosis of Moyamoya disease or Moyamoya syndrome through CT scan or angiography; If stroke occurred, being in the subacute phase (one week post-stroke); being 20 years of age or older; the ability to stand for more than 30 seconds; a MoCA score of less than 26
  • Diagnosis of stroke confirmed by brain CT or MRI, with symptom onset more than 7 days prior (subacute or chronic phase)
  • Being 20 years of age or older
  • The ability to stand for more than 30 seconds
  • a MoCA score of less than 26
  • Moyamoya disease/syndrome confirmed through CT scan or angiography
  • being in the subacute phase, defined as one week after stroke onset
  • being 20 years of age or older
  • the ability to stand for more than 30 seconds
  • a Montreal Cognitive Assessment (MoCA) score of less than 26

Ki nem vehet részt

  • unstable or uncontrolled vital signs, including a resting heart rate >100 or <40 BPM, a respiratory rate >20 or <12 breaths per minute, an SpO2 < 95%, a central arterial pressure (CAP) <80 mmHg, and individuals requiring ICP monitoring will also be excluded
  • requiring invasive mechanical ventilation or being deemed unsuitable by the attending physician due to unstable medical conditions
  • the presence of other neurological disorders or unstable vital signs may interfere with the experiment
  • unstable or uncontrolled vital signs, including a resting heart rate >100 or <40 BPM, a respiratory rate >20 or <12 breaths per minute, an SpO2 < 95%, a central arterial pressure (CAP) <80 mmHg, and individuals requiring ICP monitoring will also be excluded
  • requiring invasive mechanical ventilation or being deemed unsuitable by the attending physician due to unstable medical conditions
  • the presence of other neurological disorders or unstable vital signs may interfere with the experiment
  • unstable or uncontrolled vital signs, including a resting heart rate >100 or <40 BPM, a respiratory rate >20 or <12 breaths per minute, an SpO2 < 95%, a central arterial pressure (CAP) <80 mmHg, and individuals requiring ICP monitoring will also be excluded
  • requiring invasive mechanical ventilation or being deemed unsuitable by the attending physician due to unstable medical conditions
  • the presence of other neurological disorders or unstable vital signs that could interfere with the experiment
  • currently hospitalized in the intensive care unit (ICU)
  • Severe visual or hearing impairments, or communication and comprehension difficulties that interfere with study participation; Part 2:
  • currently hospitalized in the intensive care unit (ICU)
  • Severe visual or hearing impairments, or communication and comprehension difficulties that interfere with study participation; Part 3:
  • currently hospitalized in the intensive care unit (ICU)
  • Severe visual or hearing impairments, or communication and comprehension difficulties that interfere with study participation

Egyéb feltételek

  • Part 1:

Nézd meg, megfelelhetsz-e

Magadról válaszolj. Ez nem döntés: hogy részt vehetsz-e, azt csak a vizsgálat csapata mondhatja meg.

  • 20 és 100 év között vagy?

Helyszínek itt: Tajvan

  • National Taiwan UniversityTaipei, TajvanContact: Yan Ci LiuRésztvevőt keres

A vizsgálatról

Mit akar kideríteni a vizsgálat

The following three-part proposal will explore the impact of applying motor-cognitive incorporated training (MCIT) in individuals with post-stroke cognitive impairment (PSCI) or Moyamoya disease (MMD), and examine the relationship between cognitive and motor impairments and brain activation patterns in these populations.

A teljes eredeti leírásKevesebb

Part I is a cross-sectional study designed to characterize cognitive and motor performance and their relationship with brain activation patterns in individuals with post-stroke cognitive impairment (PSCI) or Moyamoya disease (MMD), compared to age-matched healthy controls. Thirty participants will be screened for eligibility and recruited for each group (90 participants total). After collecting basic data, all participants will undergo cognitive and motor function tests. Cognitive function tests include tests of global cognition, and executive function. Motor function tests include tests of sensorimotor function, single and dual task standing, muscle strength, and ambulation ability. Functional near-infrared spectroscopy (fNIRS) will be used to evaluate the brain activation during the cognitive tests, and single and dual task standing. Results from all tests will be used to determine the motor, cognitive, and other functional performance, and will be used in the design of the training program in Part II and III.

Part II and III are single-blinded randomized controlled trials that will explore the short and long-term effects of a motor-cognitive incorporated training (MCIT) on motor, and cognitive function in individuals with post-stroke cognitive impairment (PSCI) or Moyamoya disease (MMD). 60 individuals with PSCI (Part II), and 60 individuals with MMD (Part III) will be recruited. After screening for eligibility and collection of demographic data, participants will undergo a pretest assessment. In addition to the motor and cognitive tests used in Part I, stroke location, and time of onset will also be collected for each participant. Brain activation will be assessed during the cognitive tests, single and dual task standing assessments using fNIRS. Participants will be randomly allocated to one of the two groups (MCIT group and active control group) (n=30 in each group) via a sealed envelope selected by a blinded assistant. The training protocol is 30 minutes per session, 3 sessions per week for a total of 4 weeks. The control group will receive motor training only, including upper and lower extremity exercises, bed mobility, strengthening (core and extremities), and balance training, progressing from static to dynamic tasks. The MCIT group will engage in the program combines motor and cognitive training that starts with attention and short-term memory tasks, advancing to working memory and inhibitory control with increasing difficulty. A post-test will be conducted after the 4-week intervention, followed by follow-up assessments at 1, 3, and 12 months for individuals with PSCI or MMD in both the control group and the MCIT group. At the 3-month follow-up, participants who are unable to attend in person will be contacted by telephone. At the 12-month follow-up, all participants will receive a telephone interview focused on return-to-work status.

A vizsgálat 7 csoportja

  • No Intervention: Healthy adultsNincs vizsgálati kezelés, összehasonlításként

    Year 1: To characterize cognitive and motor performance and its relationship with brain activation patterns in individuals with post-stroke cognitive impairment (PSCI) and Moyamoya Disease (MMD).

  • Individuals with post-stroke cognitive impairmentNincs vizsgálati kezelés, összehasonlításként

    Year 1: To characterize cognitive and motor performance and its relationship with brain activation patterns in individuals with post-stroke cognitive impairment (PSCI) and Moyamoya Disease (MMD).

  • Individuals with Moyamoya DiseaseNincs vizsgálati kezelés, összehasonlításként

    Year 1: To characterize cognitive and motor performance and its relationship with brain activation patterns in individuals with post-stroke cognitive impairment (PSCI) and Moyamoya Disease (MMD).

  • Post-stroke cognitive impairment with MCIT programA vizsgált kezelés

    Year 2-3: To evaluate the short- and long-term efficacy of Motor-Cognitive Incorporated Training (MCIT) in improving cognitive and motor outcomes and modulating brain activation patterns in PSCI individuals.

    Kezelés: MCIT program

  • Post-stroke cognitive impairment with motor training programMár használt kezelés, összehasonlításként

    Year 2-3: To evaluate the short- and long-term efficacy of Motor-Cognitive Incorporated Training (MCIT) in improving cognitive and motor outcomes and modulating brain activation patterns in PSCI individuals.

    Kezelés: Motor training program

  • Moyamoya Disease with MCIT programA vizsgált kezelés

    Year 2-3: To evaluate the short- and long-term efficacy of MCIT in improving cognitive and motor outcomes and modulating brain activation patterns in MMD individuals.

    Kezelés: MCIT program

  • Moyamoya Disease with motor training programMár használt kezelés, összehasonlításként

    Year 2-3: To evaluate the short- and long-term efficacy of MCIT in improving cognitive and motor outcomes and modulating brain activation patterns in MMD individuals.

    Kezelés: Motor training program

Kérdések a vizsgálat csapatának

  1. Milyen gyakran kell bejárnom, és egy-egy alkalom mennyi ideig tart?
  2. Megtérítik az utazási költséget?
  3. Megtarthatom a saját orvosomat?
  4. Mi történik, ha ki akarok lépni?

Contact the study team: see the registry record → Contacts and Locations

Oldal nyomtatása az orvosomnak

Adatok és források

Regiszteradat
Szerepel a ClinicalTrials.gov-on.
Hivatalos cím
Impact of Cognitive-Motor Incorporated Training and Brain Activation Patterns in Cerebrovascular Diseases With Cognitive and Motor Impairments: Post Stroke Cognitive Impairment and Moyamoya Disease
MI-összefoglaló
A vizsgálat saját részvételi feltételeiből. Gépi kiolvasás: 2026. november 12.
Illeszkedési kérdések
Forrás: NCT07144930: ki vehet részt
A regiszteradat frissítve
2026. augusztus 28.