Genetic Variants in Stroke

Ki vehet részt

• Cases
• Age ≥18 years
• Confirmed diagnosis by neuroimaging (CT or MRI) of a first episode of ischemic stroke in the last 12 months
• TOAST classification of stroke available: cardioembolic, lacunar, atherosclerotic, or undetermined due to the presence of multiple sources (cardioembolic/atherosclerotic)
• Modified Rankin Scale (mRS) ≤4 at the time of inclusion
• Ability and willingness to provide consent and participate in follow-up assessments; Controls
• Age ≥18 years
• Reside in the same household or, if not, in the same neighborhood as the case group participant
• Not be a blood relative of the case group participant
• Ability and willingness to provide consent and participate in follow-up assessments

Ki nem vehet részt

• Inability to undergo magnetic resonance imaging (due to metal artifacts, MRI-incompatible implants, claustrophobia)
• Inability to undergo magnetic resonance imaging (due to metal artifacts, incompatible implants, claustrophobia)
• Ischemic stroke with a distinct etiology based on TOAST criteria (e.g., infectious, autoimmune, endocarditis, reversible cerebral vasoconstriction syndrome, drug-related causes)
• Diagnosis of monogenic or mitochondrial disorders, such as CADASIL, Fabry disease, homocystinuria, MELAS, sickle cell disease, among others
• Clinical conditions that reduce life expectancy to less than one year (e.g., neoplasia)
• Other conditions that, at the investigator's discretion, prevent participation or compromise follow-up; Controls
• Personal history of stroke, transient ischemic attack (TIA), coronary, or peripheral artery disease
• Clinical conditions that reduce life expectancy to less than one year
• Inability to provide consent due to cognitive impairment or other factors
• Diagnosis of monogenic or mitochondrial disorders, such as CADASIL, Fabry disease, homocystinuria, MELAS, or sickle cell disease
• Other conditions that, at the investigator's discretion, prevent participation or compromise follow-up
• Cases
• Serious comorbidities that may impact participation or confound the results