Orbital Vascular Inflammation in Ischemic Optic Neuropathy and Giant Cell Arteritis

MI-összefoglaló

A vizsgálat saját részvételi feltételeiből. Gép olvasta ki az oldalon álló regiszterszövegből, ezért tévedhet. Hogy ki vehet részt, azt a lenti regiszterszöveg és a vizsgálat csapata dönti el.

The trial is looking for adults aged 50 or older with new sudden damage to the optic nerve from poor blood supply, or with newly diagnosed giant cell arteritis without vision problems. Everyone will have PET/MRI scans.

Életkor

50 years or older

Nem

All sexes

A betegség stádiuma

One group: newly started suspected ischemic optic neuropathy (A-AION or NA-AION), with swelling of the optic disc, reduced vision and a pupil reflex defect (RAPD) on the same side. Other group: newly diagnosed giant cell arteritis, confirmed clinically and by ultrasound, with no vision loss or double vision, short-lived or lasting.

Korábbi kezelés

Cannot have had more than 5 days of prednisolone before joining.

A részvétel fő kizáró okai

• Metal implants that react to magnets (ferromagnetic implants)
• Severe kidney problems with eGFR < 30 mL/min/1.73m²
• Allergy to MRI contrast agents, or severe fear of closed spaces
• Pregnancy or breastfeeding
• Earlier documented optic neuropathy on the same side, or earlier giant cell arteritis

A regiszter feltételei, szó szerint

Mit akar kideríteni a vizsgálat

Giant cell arteritis (GCA) is an inflammation of the blood vessels. A dangerous complication is sudden vision loss due to insufficient blood supply to the optic nerve. However, it is often difficult to distinguish acute vision loss due to GCA from a similar condition of insufficient blood supply to the optic nerve, called NAION. Quick treatment with anti-inflammatory medication is needed in case of GCA to prevent vision loss on the eye and other serious complications. Patients with NAION have no benefit of the medication, but can have serious side effects, why it is very important to differentiate between these conditions.

A vizsgálat 2 csoportja

• Anterior ischemic optic neuropathy (AION)

  Adults aged 50 years or more with new onset AION, here defined as ipsilateral papilledema, visual impairment (affecting BCVA and/or visual field) and relative afferent pupillary defect (RAPD).

  Kezelés: Positron Emission Tomography / Magnetic Resonance Imaging

• Giant cell arteritis (GCA) without GCA-related vision loss

  Adults aged 50 years or more, newly diagnosed with GCA (clinically and ultrasound-confirmed), and without permanent or transient loss of vision or double vision.

  Kezelés: Positron Emission Tomography / Magnetic Resonance Imaging