Evaluation of Physiological and Psychological Factors Involved in Exercise Intolerance in Patients With β-TTD

Ki vehet részt

• Patients aged 18 years or older; Patients with transfusion-dependent β-thalassaemia (B0 or B+); Patients who have undergone blood transfusions at intervals of between 1 and 8 weeks for at least 5 years; Have given their free and informed written consent after being informed of the purpose of the study, its conduct and its risks; Be affiliated with a social security scheme; Not participating in any other interventional studies during the duration of this study; Control subjects must meet all of the following criteria to participate in the study:
• Subject aged 18 years or older
• Matched in age and gender to a βTTD patient included in the study
• Declaring to be free of known acute or chronic pathologies
• Have given their free written consent after being informed of the purpose of the study, its conduct and its risks
• Be affiliated with a social security scheme
• Not participate in any other interventional study during the duration of this study
• Have 'low' or 'moderate' IPAQ results (inactive or slightly active)

Ki nem vehet részt

• - Having received a bone marrow transplant
• Known concomitant medical condition that could affect compliance with the protocol
• History of thromboembolic disease
• Hospitalised for cardiac decompensation in the last 12 months
• Lack of use of limbs (amputee, paraplegic, quadriplegic)
• Unable to comply with protocol requirements for social, family or other reasons, as determined by the investigator
• benefiting of enhanced protection, namely minors, persons deprived of their liberty by judicial or administrative decision, adults under legal protection and, finally, patients in emergency situations
• Unable to give consent
• Pregnant or breastfeeding women