Development of Optimal Sensory Feedback Strategies to Maximize Function After Tetraplegia

MI-összefoglaló

A vizsgálat saját részvételi feltételeiből. Gép olvasta ki az oldalon álló regiszterszövegből, ezért tévedhet. Hogy ki vehet részt, azt a lenti regiszterszöveg és a vizsgálat csapata dönti el.

The trial is looking for people with tetraplegia from a neck spinal cord injury who are already in the ReHAB trial. They must already have the ReHAB implants in the brain and arm.

Életkor

22 Years to 65 Years

Nem

All sexes can join.

A betegség stádiuma

Spinal cord injury in the neck (cervical) causing tetraplegia. Complete or incomplete injuries.

Korábbi kezelés

Must be enrolled in the ReHAB clinical trial and have had surgery to implant the ReHAB system parts.

A részvétel fő kizáró okai

• None of the implanted ReHAB system parts work
• Severe pain that would stop you from doing the study tasks
• Another long-term medical condition that would stop you from doing the study tasks

A regiszter feltételei, szó szerint

Nézd meg, megfelelhetsz-e

Magadról válaszolj. Ez nem döntés: hogy részt vehetsz-e, azt csak a vizsgálat csapata mondhatja meg.

• 22 és 65 év között vagy?IgenNem

Mit akar kideríteni a vizsgálat

The goal of this clinical trial is to learn more about how stimulating the nerves involved in sensation (either in the limbs or in the brain) can be used to restore sensation in participants who have a spinal cord injury. Participants in this study will have already been enrolled in the "Reconnecting the Hand and Arm to the Brain (ReHAB)" study, and received small electrodes in a part of the brain that is involved in sensing touch and pressure in the hand. The ReHAB study participants will also have received electrodes around the nerves in their arm. In this clinical trial, participants will receive two types of electrical stimulation:

A vizsgálat csoportja

• Intracortical microstimulation and peripheral nerve stimulation for people with tetraplegiaA vizsgált kezelés

  The purpose of the proposed study is to investigate the perception and functional impact of sensory neurostimulation in participants with tetraplegia. Investigators will develop and implement novel paradigms of intracortical microstimulation (ICMS) applied to primary somatosensory cortex (S1) and peripheral nerve stimulation (PNS) applied to upper extremity nerves through chronically-implanted cuff electrodes. Investigators will also develop and assess hybrid neurostimulation paradigms involving paired application of ICMS and PNS. For each paradigm, investigators will quantify the perceived sensation with classic psychophysical methods. Investigators will also implement the approach into closed-loop tasks in virtual reality controlled through decoded cortical signals recorded from intracortical microelectrode arrays. Finally, investigators will assess the impact of each stimulation paradigm on residual sensory function.

  Kezelés: Brain Computer Interface (BCI) - Functional Electrical Stimulation (FES) system