Neural Mechanisms of Light Driven Analgesia

MI-összefoglaló

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The trial is looking for adults with chronic muscle and joint pain (including fibromyalgia) and healthy adults. It studies how colored light changes brain activity and pain during MRI scans. 2 people with congenital stationary night blindness and no chronic pain will also join.

Életkor

18 years or older

Nem

All sexes

A betegség stádiuma

People with pain must score ≥7 on the Widespread pain index (WPI) and ≥5 on the symptom severity scale (SSS), or 4-6 on the WPI and ≥9 on the SSS (2016 Fibromyalgia Questionnaire). Pain must have lasted 3 months or longer, be in 4 out of 5 body regions, and average ≥4 on a 0-10 scale over the past month.

Korábbi kezelés

No planned changes to medicines or treatment for the next 3 months.

A részvétel fő kizáró okai

• Eye or retina problems that harm vision, such as uveitis, cataracts or color-blindness
• Sensitivity to or dislike of light
• History of seizures
• Pregnancy
• Cannot have an MRI, for example metal implants, devices not safe for MRI, or fear of closed spaces

A regiszter feltételei, szó szerint

Mit akar kideríteni a vizsgálat

The goal of this study will be to understand the biological mechanisms that are responsible to light-driven analgesia. Light presented to the retina has been shown to have pain relieving properties in pre-clinical and clinical studies. In this study the investigators will evaluate the functional connectivity between subcortical visual areas and non-image forming brain areas that are involved in pain sensation. The investigators will also evaluate how three colored light stimuli presented to the retina results in changes in whole brain evoked activation patterns in participants with chronic musculoskeletal pain and in healthy controls. The investigators will also assess while brain evoked activation patterns in response to a pressure pain stimulus in the presence of three light stimuli in individuals with chronic musculoskeletal pain and healthy controls.

A vizsgálat csoportja

• Light sequence during imagingA vizsgált kezelés

  The sequence of stimulus presentation for resting state scans will be Equal Energy White (with luminance modulation) for 8 minutes then Static Green for 8 minutes, followed by an anatomical scan, then S-cone modulating stimuli for 8 minutes.

  Kezelés: S-cone modulating visual stimulus, Equal Energy White Visual Stimulus, Green light visual stimulus (S-OFF) és Evoked Pressure Pain Stimulus