Dose Escalation and Dose Expansion Study of MDX2003 in Patients With Different Types of Lymphoma

Ki vehet részt

• Participant must be ≥ 18 years of age
• Participant has a confirmed diagnosis of large B-cell lymphoma (including DLBCL, high-grade B-cell lymphoma [HGBCL], primary mediastinal B-cell lymphoma [PMBCL], etc), FL, MCL, marginal zone lymphoma, transformation of indolent B-cell lymphoma, or lymphoplasmacytic lymphoma, including Waldenstrom macroglobulinemia
• Participant has relapsed or progressed on at least 2 prior lines of therapy
• Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 2
• All participants must have measurable disease via computed tomography (CT), magnetic resonance imaging (MRI), or positron emission tomography (PET)-CT
• Documented CD19 or CD20 positivity of their B-cell neoplasm based on any representative pathology report from the past 3 months
• Adequate hematologic, hepatic and renal function
• All contraceptive use by men and women should be consistent with local regulations regarding the methods of contraception for those participating in clinical studies
• Capable of giving signed informed consent

Ki nem vehet részt

• Unresolved toxicities from previous anticancer therapy
• Active medical condition requiring chronic systemic steroid use (>10 mg/day prednisone or equivalent of >140 mg over the last 14 days) or immunosuppressive therapy, within 6 months prior to the first dose of MDX2003
• Known or suspected history of hemophagocytic lymphohistiocytosis (HLH)
• Known positivity with human immunodeficiency virus (HIV), known active hepatitis B or C, or uncontrolled chronic or ongoing infection requiring intravenous treatment
• Participant has a history of allogenic tissue or solid organ transplant, with the exception of corneal transplants
• Known hypersensitivity to allopurinol or rasburicase
• Participant has a seizure disorder requiring therapy at the time of screening (such as steroids or anti-epileptics)
• Participant is not suitable for participation, whatever the reason, as judged by the Investigator, including medical or clinical conditions
• Primary central nervous system (CNS) lymphoma or known CNS involvement with lymphoma