PREcision meDICine in Treatment in CardioVascular Disease

Ki vehet részt

• Provide written and dated informed consent for participation prior to trial admission,
• Age ≥18 years, female or male
• Diagnosis of heart failure* either before discharge of a heart failure hospital admission or in the outpatient setting,
• Symptomatic, defined as NYHA class II - IV,
• LVEF < 50% measured in the last 12 months (using any modality), with no occurrence of HF event(s) since that measurement) and
• Those not previously treated with evidence-based therapies or sub-optimally treated with GDMT defined as; • Not treated with one of the foundational four** HF medication unless absolute contraindication or documented intolerance; Definition of heart failure according to the most recent Heart Failure Guidelines of the European Society of Cardiology; Foundational four heart failure medication: BBs, ARNi, MRAs and SGLT2i. NB. This does not include ACE and ARBs these are permitted

Ki nem vehet részt

• Scheduled or on renal replacement therapy,
• Requiring valvular surgery or revascularization in the upcoming 3 months or revascularization within the past 3 months,
• Scheduled for mechanical assist device or heart transplant,
• Acute coronary syndrome (ACS) in the past 3 months or current angina pectoris ≥class III,
• Anticipated need for surgery or any cardiovascular intervention, except implantable cardioverter defibrillator and/or cardiac resynchronization therapy, within 4 weeks,
• Other non-cardiac conditions with limited life expectancy (≤ duration of the trial/ 1 year),
• Inability to understand and sign informed consent,
• Clearly documented intolerance to BBs, ARNI, SGLT2i or MRAs
• Diagnosis of acute myocarditis or (non)obstructive hypertrophic cardiomyopathy,
• The presence of a mechanical assist device,
• Participation in another (intervention) clinical trial (registry studies not included) until the onsite EoS visit (V5) at 9 months has been completed
• Women who are pregnant, breastfeeding or may be considering pregnancy during the study duration