Autophagy-Enhancers to Reduce Sleep Disturbances

Ki vehet részt

• Men and women
• Written consent to participate in the study
• German at native speaker level
• Age between 55 and 75 years
• Subjective Cognitive Decline operationalized as:; Subjectively reported decline in cognitive function (particularly memory) despite objectively normal cognitive performance (e.g., WMS-LM); Preservation of functional independence; No dementia
• Men and women
• Written consent to participate in the study
• German at native speaker level
• Age between 55 and 75 years
• Mild cognitive impairment (MCI) operationalized as:; A change in cognitive abilities reported by the patient, relatives or clinic staff (i.e. historical or observed evidence of deterioration over time); Objective evidence of memory impairment (at least 1.0 Standard Deviation (SD) below the normal range on the Wechsler Logical Memory Scale (WMS-LM)); other cognitive domains may also be affected (i.e. amnestic MCI and amnestic + MCI); Preservation of independence of functional abilities; No dementia
• Men and women
• Written consent to participate in the study
• German at native speaker level
• Age between 55 and 75 years
• Subjective cognitive disorders are denied

Ki nem vehet részt

• Previous stroke
• Current or previous substance abuse
• Previous stroke
• Dementia according to the Diagnostic and Statistical Manual of Mental Disorders, 4th Edition (DSM-IV)
• Any condition that impairs clinical or neuropsychological examination procedures
• Diabetes mellitus
• Polycystic ovary syndrome
• Signs of epilepsy, focal brain lesion or head injury with loss of consciousness or immediate post-injury confusion
• Severe untreated medical problems or unstable medical condition
• Psychotic disorder
• Bipolar disorder
• Other neurodegenerative disease, e.g. Parkinson's disease
• Vascular dementia
• Sleep disorders
• Taking medication that primarily affects the central nervous system (e.g. antipsychotics, antidepressants, benzodiazepines or any type of over-the-counter sleep-inducing medication such as valerian; anti-dementia medication)
• Known intolerances or allergies to wheat germ, gluten or histamine
• Dementia according to the Diagnostic and Statistical Manual of Mental Disorders, 4th Edition (DSM-IV)
• Mild cognitive impairment (MCI), defined as described above in the patient inclusion criteria
• Any condition that interferes with clinical or neuropsychological examination procedures
• Diabetes mellitus
• Polycystic ovary syndrome
• Signs of epilepsy, focal brain lesion or head injury with loss of consciousness or immediate post-injury confusion
• Severe untreated medical problems or unstable medical condition
• Psychotic disorder
• Bipolar disorder
• Other neurodegenerative disease, e.g. Parkinson's disease
• Vascular dementia
• Sleep disorders
• Taking medication that primarily affects the central nervous system (e.g. antipsychotics, antidepressants, benzodiazepines or any type of over-the-counter sleep-inducing medication such as valerian; anti-dementia medication)
• Patients who are unable to give informed consent
• Polyamine intake via dietary supplements and/or participation in corresponding intervention studies
• Current major depressive episode
• Alcohol abuse
• Participation in an interventional study in the last 3 months and during the entire study period
• Subjects who are not able to give informed consent
• Polyamine intake via dietary supplements and/or participation in corresponding intervention studies
• Current major depressive episode
• Current or past substance abuse
• Alcohol abuse
• Participation in an interventional study in the last 3 months and during the entire study period