Remote Ischemic Conditioning and Spinal Reflex Modulation in Children With Cerebral Palsy

MI-összefoglaló

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The trial is looking for children aged 8-17 years with cerebral palsy (CP) who go to a mainstream school. It tests brief blood pressure cuff squeezes on the thigh together with balance training.

Életkor

8 to 17 years

Nem

All sexes

A betegség stádiuma

Cerebral palsy at Gross Motor Function Classification System levels I-III (from walking without limits to walking with a hand-held aid).

Korábbi kezelés

Children getting other add-on therapies, such as transcranial magnetic stimulation, transcranial direct current stimulation or vagal nerve stimulation, cannot join.

A részvétel fő kizáró okai

• Other developmental disabilities, such as autism or developmental coordination disorder
• Problems with thinking, understanding commands or communication, or much lower school performance than grade level
• Balance disorders, such as inner-ear (vestibular) disorders or posterior fossa tumor, or known heart or lung problems
• Sickle cell disease, or being pregnant
• A leg condition, injury or surgery in the last three months

A regiszter feltételei, szó szerint

Nézd meg, megfelelhetsz-e

Magadról válaszolj. Ez nem döntés: hogy részt vehetsz-e, azt csak a vizsgálat csapata mondhatja meg.

• 8 és 17 év között vagy?IgenNem

Mit akar kideríteni a vizsgálat

Remote ischemic conditioning (RIC) is a clinically feasible intervention involving brief, sublethal periods of ischemia followed by reperfusion that has been shown to enhance motor performance, strength, and balance when combined with training in healthy adults and individuals with neurological conditions. Although RIC is thought to influence neuroplasticity through neural, metabolic, and humoral pathways, its effects on spinal-level mechanisms remain poorly understood. Emerging evidence indicates that neuroplastic adaptations occur not only at the cortical level but also within the spinal cord. Moreover, altered spinal reflex excitability is associated with spasticity, balance impairments, and functional limitations in children with cerebral palsy (CP), yet the role of spinal reflex modulations in response to RIC and balance training remains under expplored in this population. Therefore, this study aims to investigate the effects of RIC combined with balance training on spinal reflex modulation in children with CP.

A vizsgálat 2 csoportja

• Remote Ischemic Conditioning (RIC)A vizsgált kezelés

  RIC is achieved via blood pressure cuff inflation to at least 20 mmHg above systolic blood pressure to 200 mmHg on the thigh of more affected lower extremity. RIC involves 5 cycles of 5 minutes blood pressure cuff inflation followed by alternating 5 minutes of cuff deflation and requires 45 minutes. RIC is performed on visits 1 - 5.

  Kezelés: Remote Ischemic Condtioning (RIC) és Sham conditioning

• Sham conditioningSzínlelt kezelés, összehasonlításként

  Sham conditioning is achieved via blood pressure cuff inflation to 25 mm Hg on the thigh of the more affected LE. Sham involves 5 cycles of 5 minutes blood pressure cuff inflation followed by alternating 5 minutes of cuff deflation and requires 45 minutes. Sham conditioning is performed on visits 1-5.

  Kezelés: Sham conditioning és Balance training