IL-33, sST2, and CRP in Panic Disorder
A legfontosabb adatok
- Ki végzi
- Elazığ Mental Health and Diseases Hospital
- Hol
- Törökország1 helyszín, 1 országbanVálassz országot a helyszínekhez
- Azonosító
- Állapot
- Befejeződött
- Résztvevők
- 71 fő vett részt
- Kezdés
- 2025. júl. 7.
- Befejezés
- 2026. márc. 5.
- A vizsgálat típusa
- Megfigyeléses, 2 csoport
- A regiszteradat frissítve
- 2026. október 26.
Ki vehet részt
- Életkor
- 18 év – 65 év
- Nem
- Nők és férfiak
- Egészséges önkéntesek
- Részt vehetnek
A regiszter feltételei, szó szerint
Mind a 2 feltétel megnézéseKevesebb
Egyéb feltételek
- For Panic Disorder (PD) Group:; *Inclusion Criteria:; Being between 18-65 years of age; Having a diagnosis of panic disorder (PD) according to DSM-5-TR and having presented to the hospital with panic attack symptoms of the disorder; Not having previously used any medication for psychiatric purposes (drug-naive); Not having any additional active psychiatric disorders besides PD at the current presentation; Absence of hypertension, diabetes mellitus, renal failure, hepatic failure, neurological disease with cognitive impairment, acute infection, pregnancy, autoimmune disease, or cancer; Not having taken any medication or supplements in the last month; Completing sociodemographic and scale data fully; Volunteering to participate in the study; For PD Group:; *Exclusion Criteria:; Being outside the 18-65 age range; Not meeting the diagnostic criteria for PD according to DSM-5-TR or being in good health; Having a history of psychiatric medication use; Having an additional psychiatric disorder besides PD at the current application; Presence of hypertension, diabetes mellitus, renal failure, hepatic failure, neurological disease with cognitive impairment, acute infection, pregnancy, autoimmune disease, cancer; Taking any medication or supplement in the last month; Incomplete completion of sociodemographic and scale data; Not volunteering to participate in the study
- For Healthy Control Group:; *Inclusion Criteria:; Being between 18-65 years of age; Not having any active psychiatric disorder; Not having previously used any medication for psychiatric purposes (drug-naive); Not having hypertension, diabetes mellitus, kidney failure, liver failure, neurological disease with cognitive impairment, acute infection, pregnancy, autoimmune disease, or cancer; Not having taken any medication or supplement in the last month; Completing sociodemographic and scale data fully; Volunteering to participate in the study; For Healthy Control Group:; *Exclusion Criteria:; Being outside the 18-65 age range; Having any active psychiatric disorder; Having a history of using psychiatric medication; Having hypertension, diabetes mellitus, renal failure, hepatic failure, neurological disease with cognitive impairment, acute infection, pregnancy, autoimmune disease, or cancer; Taking any medication or supplement in the last month; Incomplete completion of sociodemographic and scale data; Not volunteering to participate in the study
Ennek a vizsgálatnak nincs helyszíne itt: Egyesült Államok.
Egy országban van helyszíne. Válassz országot, hogy lásd a helyszíneket.
A vizsgálatról
Mit akar kideríteni a vizsgálat
Panic disorder (PD) is characterized by recurrent and unexpected panic attacks and is associated with significant functional impairment. Increasing evidence suggests involvement of immune-inflammatory mechanisms in PD. Elevated levels of inflammatory markers such as C-reactive protein (CRP) have been reported in PD; however, interleukin-33 (IL-33) and soluble suppressor tumorogenicity-2 (sST2), components of the IL-33/sST2 signaling axis, have not previously been investigated in PD. This cross-sectional case-control study aims to compare peripheral serum IL-33, sST2, and CRP levels between drug-naïve subjects diagnosed with PD and healthy controls (HCs). The findings may contribute to understanding the inflammatory mechanisms underlying PD.
A vizsgálat 2 csoportja
- Panic Disorder (PD)
Adult participants (18-65 years) diagnosed with panic disorder (PD) according to DSM-5-TR criteria. All of the subjects with PD was drug-naive. Subjects were evaluated at baseline. No intervention was assigned by the study protocol. Blood samples were collected for measurement of serum interleukin-33 (IL-33) and soluble suppressor tumorogenicity-2 (sST2), and C-reactive protein (CRP) levels and complete blood count parameters. Clinical assessments in the PD group included the DSM-5 Panic Disorder Severity Scale (Adult Form). Sociodemographic and clinical data were recorded for all participants.
- Healthy Control (HC)
Healthy control adult participants (18-65 years) without any current or past psychiatric disorder. No intervention was administered as part of the research protocol. Participants underwent a baseline clinical evaluation and provided a single blood sample for measurement of serum serum interleukin-33 (IL-33) and soluble suppressor tumorogenicity-2 (sST2), and C-reactive protein (CRP) levels and complete blood count parameters.
Adatok és források
- Regiszteradat
- Szerepel a ClinicalTrials.gov-on.
- Hivatalos cím
- Investigation of IL-33, sST2, and C-Reactive Protein in Panic Disorder: A Cross-Sectional Case-Control Study
- A regiszteradat frissítve
- 2026. október 26.