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IL-33, sST2, and CRP in Panic Disorder

A legfontosabb adatok

Ki végzi
Elazığ Mental Health and Diseases Hospital
Hol
Törökország1 helyszín, 1 országbanVálassz országot a helyszínekhez
Azonosító
Állapot
Befejeződött
Résztvevők
71 fő vett részt
Kezdés
2025. júl. 7.
Befejezés
2026. márc. 5.
A vizsgálat típusa
Megfigyeléses, 2 csoport
A regiszteradat frissítve
2026. október 26.

Ki vehet részt

Életkor
18 év – 65 év
Nem
Nők és férfiak
Egészséges önkéntesek
Részt vehetnek

A regiszter feltételei, szó szerint

Mind a 2 feltétel megnézéseKevesebb

Egyéb feltételek

  • For Panic Disorder (PD) Group:; *Inclusion Criteria:; Being between 18-65 years of age; Having a diagnosis of panic disorder (PD) according to DSM-5-TR and having presented to the hospital with panic attack symptoms of the disorder; Not having previously used any medication for psychiatric purposes (drug-naive); Not having any additional active psychiatric disorders besides PD at the current presentation; Absence of hypertension, diabetes mellitus, renal failure, hepatic failure, neurological disease with cognitive impairment, acute infection, pregnancy, autoimmune disease, or cancer; Not having taken any medication or supplements in the last month; Completing sociodemographic and scale data fully; Volunteering to participate in the study; For PD Group:; *Exclusion Criteria:; Being outside the 18-65 age range; Not meeting the diagnostic criteria for PD according to DSM-5-TR or being in good health; Having a history of psychiatric medication use; Having an additional psychiatric disorder besides PD at the current application; Presence of hypertension, diabetes mellitus, renal failure, hepatic failure, neurological disease with cognitive impairment, acute infection, pregnancy, autoimmune disease, cancer; Taking any medication or supplement in the last month; Incomplete completion of sociodemographic and scale data; Not volunteering to participate in the study
  • For Healthy Control Group:; *Inclusion Criteria:; Being between 18-65 years of age; Not having any active psychiatric disorder; Not having previously used any medication for psychiatric purposes (drug-naive); Not having hypertension, diabetes mellitus, kidney failure, liver failure, neurological disease with cognitive impairment, acute infection, pregnancy, autoimmune disease, or cancer; Not having taken any medication or supplement in the last month; Completing sociodemographic and scale data fully; Volunteering to participate in the study; For Healthy Control Group:; *Exclusion Criteria:; Being outside the 18-65 age range; Having any active psychiatric disorder; Having a history of using psychiatric medication; Having hypertension, diabetes mellitus, renal failure, hepatic failure, neurological disease with cognitive impairment, acute infection, pregnancy, autoimmune disease, or cancer; Taking any medication or supplement in the last month; Incomplete completion of sociodemographic and scale data; Not volunteering to participate in the study

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A vizsgálatról

Mit akar kideríteni a vizsgálat

Panic disorder (PD) is characterized by recurrent and unexpected panic attacks and is associated with significant functional impairment. Increasing evidence suggests involvement of immune-inflammatory mechanisms in PD. Elevated levels of inflammatory markers such as C-reactive protein (CRP) have been reported in PD; however, interleukin-33 (IL-33) and soluble suppressor tumorogenicity-2 (sST2), components of the IL-33/sST2 signaling axis, have not previously been investigated in PD. This cross-sectional case-control study aims to compare peripheral serum IL-33, sST2, and CRP levels between drug-naïve subjects diagnosed with PD and healthy controls (HCs). The findings may contribute to understanding the inflammatory mechanisms underlying PD.

A vizsgálat 2 csoportja

  • Panic Disorder (PD)

    Adult participants (18-65 years) diagnosed with panic disorder (PD) according to DSM-5-TR criteria. All of the subjects with PD was drug-naive. Subjects were evaluated at baseline. No intervention was assigned by the study protocol. Blood samples were collected for measurement of serum interleukin-33 (IL-33) and soluble suppressor tumorogenicity-2 (sST2), and C-reactive protein (CRP) levels and complete blood count parameters. Clinical assessments in the PD group included the DSM-5 Panic Disorder Severity Scale (Adult Form). Sociodemographic and clinical data were recorded for all participants.

  • Healthy Control (HC)

    Healthy control adult participants (18-65 years) without any current or past psychiatric disorder. No intervention was administered as part of the research protocol. Participants underwent a baseline clinical evaluation and provided a single blood sample for measurement of serum serum interleukin-33 (IL-33) and soluble suppressor tumorogenicity-2 (sST2), and C-reactive protein (CRP) levels and complete blood count parameters.

Adatok és források

Regiszteradat
Szerepel a ClinicalTrials.gov-on.
Hivatalos cím
Investigation of IL-33, sST2, and C-Reactive Protein in Panic Disorder: A Cross-Sectional Case-Control Study
A regiszteradat frissítve
2026. október 26.