Correlation of Inflammatory Markers and Radiological Findings in Stable Bronchiectasis Patients With Exacerbation Phenotype

MI-összefoglaló

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The trial is looking for adults with bronchiectasis not caused by cystic fibrosis. Bronchiectasis means the airways are widened for good. The trial compares blood markers of inflammation with lung scan findings.

Életkor

18 years and older

Nem

All sexes

A betegség stádiuma

Non-cystic fibrosis bronchiectasis, confirmed by a High Resolution Computed Tomography (HRCT) lung scan.

A részvétel fő kizáró okai

• Bronchiectasis caused by cystic fibrosis
• Active tuberculosis of the lungs
• Serious long-term illness, such as advanced liver or kidney disease
• Autoimmune disease or cancer that needs immune-lowering treatment when the markers are measured
• Not wanting to take part

A regiszter feltételei, szó szerint

Mit akar kideríteni a vizsgálat

Bronchiectasis, also referred to as non-cystic fibrosis (non-CF) bronchiectasis, is a chronic respiratory disease defined by abnormal and irreversible dilatation of the bronchi (1). Dilatation of the bronchial lumen predisposes to infection (2). Recurrent infection and airway inflammation leads to tissue damage and inflammation that leads to excess mucus production and delayed mucociliary clearance, predisposing the patient to recurrent and chronic infections (3). This in turn creates a cycle of further tissue damage and infection (4), leading to recurrent exacerbations, hospitalizations and loss of lung function. Non-CF bronchiectasis patients who experience frequent exacerbations (≥2 per year) represent a high-risk group with accelerated disease progression.Bronchiectasis has become a major health concern due to its increasing prevalence and associated healthcare costs (5). The disease can be caused by many different etiologies, which may be causative, synergistic, or coincidental, depending on the manner in which they interact and it is clinically characterized by a variety of symptoms, including cough, sputum production and airway infection, and can often present with recurrent exacerbations (6). An exacerbation is generally defined as a sustained clinical deterioration characterized by an increase in symptoms, which may include increased cough, increased sputum volume or change in consistency, increased sputum purulence (color change), increased breathlessness and/or reduced exercise tolerance, increased fatigue and/or malaise, hemoptysis for at least 48 h requiring a change in treatment.

A vizsgált kezelések

• Inflammatory Markers and Radiological Findings