Methotrexate Treatment in Hand Osteoarthritis Refractory to Usual Treatments

Ki vehet részt

• Digital osteoarthritis (IPD and IPP) according to ACR criteria (with an X-ray of the hands taken less than 3 months ago, showing at least 3 joints with digital osteoarthritis KL>=2) and symptomatic for more than three months

Ki nem vehet részt

• Injection of hyaluronic acid within the previous 6 months,
• Injection of cortisone derivatives within the previous 3 months,
• Use of corticosteroids
• Major progressive disease (life-threatening cardiovascular disease, hematopoietic cancers including myeloma, cancers with risk of bone metastases),
• Liver failure
• Positive hepatitis B serology
• Tuberculosis, hepatitis C, HIV positive, or other immunodeficiency syndromes
• Uncontrolled infections
• Having a bilirubin level > 5 mg/dl (85.5 µmol/l)
• Severe renal failure (creatinine clearance less than 50 ml/min)
• Pregnant or breastfeeding women (a urine pregnancy test will be performed on women of childbearing age),
• Presence of psoriasis,
• Inflammatory rheumatism,
• Microcrystalline arthropathy,
• Joint prosthesis in one of the joints of the hand,
• Planned placement of a joint prosthesis in the hand during the study period,
• Use of morphine derivatives,
• Taking Bactrim,
• Taking high doses of aspirin (greater than or equal to 500mg/day),
• Contraindications to the use of methotrexate,