Simplified Exercise-based Risk Assessment in Lung Cancer

MI-összefoglaló

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Életkor

18 éves vagy idősebb

Nem

Nemtől függetlenül bárki részt vehet

A betegség stádiuma

Tüdőrák-diagnózis

A részvétel fő kizáró okai

• Nem tud kerékpár-ergométeres gyakorlatot végezni
• Nem érti a beszélt vagy írott svéd nyelvet

A regiszter feltételei, szó szerint

Mit akar kideríteni a vizsgálat

Physiological evaluation is part of the preoperative risk estimation in patients with lung cancer, and it aids in the choice of treatment. Ventilatory efficiency during exercise has emerged as a strong predictor of major postoperative complications, so far determined during a maximal cardiopulmonary exercise test. However, this test is limited by its availability and high cost, due to the requirement of high-technological equipment and advanced expertise. The current project aims to evaluate a simplified and accessible method for risk evaluation before decision on treatment in lung cancer. It builds on recent advances in technology and knowledge and combines a simple, low-intensity cycling test with measurement of ventilatory efficiency (end-tidal carbon dioxide pressure) with a handheld monitor. In a prospective, multi-center design the investigators will include patients evaluated for suspected lung cancer. The main objective is to establish threshold values for end-tidal carbon dioxide associated with low respectively high risk of major complications in patients undergoing surgery. In addition, the study aims to determine if end-tidal carbon dioxide can predict severe side-effects during neoadjuvant or curatively aiming systemic therapy. The project is closely linked to clinical practice, and the results can be easily implemented due to the simple and cost-efficient methodology. the suggested simplified approach would also allow access to physiological evaluation where more advanced methods are unavailable.

A vizsgálat 4 csoportja

• Primary objective cohort - Lung cancer lobectomy

  For primary objective, patients undergoing lobectomy for lung cancer will be studied.

• Neoadjuvant treatment cohort

  As one secondary objective, patients with lung cancer undergoing neoadjuvant treatment before surgery or other non-surgical treatment will be studied separately

• Sub-lobular resection cohort

  As one secondary objective, patients undergoing sublobular resection for lung cancer will be studied separately.

• Non-surgical treatment cohort

  As one secondary objective, patients undergoing other treatment than surgery for lung cancer will be studied.