Impact of Transcatheter Aortic Valve Implantation and Mitral Valve Repair on Sleep-Disordered Breathing

MI-összefoglaló

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The trial is looking for adults who are having TAVI (a new aortic heart valve placed through a catheter) or M-TEER (mitral valve repair through a catheter). It studies how these procedures change breathing problems during sleep.

Életkor

18 years and older

Nem

All sexes

A betegség stádiuma

Severe aortic valve narrowing (aortic stenosis) treated with TAVI, or severe leaking mitral valve (mitral regurgitation) treated with M-TEER.

Korábbi kezelés

People must be going to have TAVI or M-TEER.

A részvétel fő kizáró okai

• Not able to have an overnight sleep study (polysomnography)
• Not able to come back for the check at 6 months
• Problems with memory or thinking, such as dementia
• Not willing to take part

A regiszter feltételei, szó szerint

Mit akar kideríteni a vizsgálat

This prospective observational study aims to investigate the impact of transcatheter aortic valve implantation (TAVI) and transcatheter mitral valve edge-to-edge repair (M-TEER) on sleep-disordered breathing (SDB) in patients with significant valvular heart disease. Patients undergoing TAVI or M-TEER will be evaluated with full polysomnography prior to the intervention and at 6 months follow-up. Changes in sleep parameters, including apnea-hypopnea index (AHI), central and obstructive apnea indices, oxygen desaturation, and sleep architecture, will be assessed. In addition, the study will explore the association between changes in SDB and echocardiographic as well as arrhythmic parameters. The findings are expected to improve the understanding of the interaction between valvular heart disease and SDB and to identify potential benefits of transcatheter interventions on sleep-related outcomes.

A vizsgálat 2 csoportja

• TAVI Group

  Patients undergoing TAVI for severe aortic stenosis.

• M-TEER Group

  Patients undergoing M-TEER for severe mitral regurgitation.