Dorsal Root Ganglion Stimulation After Lower Motor Neuron Damage

Ki vehet részt

• Traumatic and non-traumatic spinal cord injury (SCI)
• ASIA Impairment Scale (AIS) A-D
• SCI below the tenth thoracic vertebral level
• Greater than 1 year post-SCI
• Intact spinal reflexes at or below injury level in 1 or more muscles

Ki nem vehet részt

• Active, untreated urinary tract infection
• Unhealed decubitus ulcer
• Untreated clinical diagnosis of psychiatric disorder
• Other implanted stimulation devices (e.g., deep brain stimulator, cardiac pacemaker, diaphragmatic pacer, etc.)
• History of clinically diagnosed cardiopulmonary disorder, such as severe orthostatic hypotension, which may impede participation in rehabilitation activities such as changes in body position such as supine-to-sit-to-stand activities, prolonged standing, or stepping
• History of frequent and/or severe autonomic dysreflexia
• History of seizure disorder
• Any illness or condition which, based on the research team's assessment, will compromise with the patient's ability to comply with the protocol, patient safety, or the validity of the data collected during this study
• Currently a prison inmate, or awaiting trial, related to criminal activity
• Pregnancy at the time of screening for trial enrollment
• Unhealed skeletal fracture
• Spinal abnormality that may impede percutaneous implantation of spinal electrodes
• Joint contractures that impede typical range of motion
• Non-MRI-compatible implanted medical devices
• Active participation in an interventional clinical trial which, based on the research team's assessment, may compromise protocol compliance, safety, and/or validity of data collected during this study