A Study of Lipid Metabolism and Mitochondrial Function in Myeloid Cells and Total Aortic Tissue in Patients With Ascending Thoracic Aortic Aneurysm (ATA) and Bicuspid (BA) or Tricuspid (TA) Aortic Valves.

MI-összefoglaló

A vizsgálat saját részvételi feltételeiből. Gép olvasta ki az oldalon álló regiszterszövegből, ezért tévedhet. Hogy ki vehet részt, azt a lenti regiszterszöveg és a vizsgálat csapata dönti el.

The trial is looking for adults with a bulge (aneurysm) of the ascending aorta who have planned surgery to replace it. People with a two-leaflet (bicuspid) or three-leaflet (tricuspid) aortic valve can join.

Életkor

Over 18 years

Nem

All

A betegség stádiuma

Ascending aortic aneurysm that needs surgical replacement, with surgery scheduled. Emergency surgery is not allowed.

Korábbi kezelés

No past heart surgery.

Biomarker vagy leletérték

An ultrasound before surgery must confirm the valve type (bicuspid or tricuspid).

A részvétel fő kizáró okai

• Pregnant, in labor or breastfeeding
• Confirmed or suspected inherited aneurysm, such as Marfan, Loeys-Dietz or Ehlers-Danlos syndrome
• Uncontrolled inflammatory or autoimmune disease, or a condition needing immunosuppressants
• Recent acute infection (within the last 3 months or still being treated)
• Under guardianship or unable to give consent

A regiszter feltételei, szó szerint

Mit akar kideríteni a vizsgálat

Ascending aortic aneurysms (AAAs) are serious conditions that can lead to aortic dissections or ruptures, carrying a high risk of mortality. Their pathophysiology is based on complex mechanisms involving inflammatory and metabolic processes, as well as alterations in mitochondrial function. The presence of a bicuspid aortic valve (BAV) or tricuspid aortic valve (TAV) significantly influences the progression and severity of aneurysms. Bicuspid aortic valve (BAV) patients often develop aortic aneurysms earlier, as early as age 40-50, whereas tricuspid aortic valve (TAV) patients generally present with a degenerative condition that appears later (after age 50). The objective of this study is to compare the inflammatory, metabolic, and transcriptomic signatures of myeloid cells and total aortic tissue between BAV and TAV patients. These analyses will help identify specific molecular mechanisms, potential biomarkers, and therapeutic targets. To ensure pathophysiological homogeneity, patients with aneurysms of genetic origin (Marfan syndrome, Loeys-Dietz syndrome, Ehlers-Danlos syndrome, etc.) will be excluded.

A vizsgálat 2 csoportja

• Patient with an ascending aortic aneurysm and a bicuspid aortic valve (BAV)

  Kezelés: Additional blood samples és Collection of discarded ascending aortic tissue

• Patient with an ascending aortic aneurysm and a tricuspid aortic valve (TAV)

  Kezelés: Additional blood samples és Collection of discarded ascending aortic tissue