Knee Ligament Stiffness Across Ethnicities Before and After Osteoarthritis Treatment

MI-összefoglaló

A vizsgálat saját részvételi feltételeiből. Gép olvasta ki az oldalon álló regiszterszövegből, ezért tévedhet. Hogy ki vehet részt, azt a lenti regiszterszöveg és a vizsgálat csapata dönti el.

The trial is looking for healthy adults and adults with painful knee osteoarthritis. It measures knee ligament stiffness with an ultrasound method called shear wave elastography.

Életkor

20 years or older.

Nem

All sexes can join.

A betegség stádiuma

Healthy volunteers: no pain in either knee in the past 6 months, and able to walk without aids. Patients: knee pain in at least one knee in the past year, knee pain, soreness or stiffness in the past month, and osteoarthritis seen on X-ray (Kellgren-Lawrence grade ≥2, or bony spurs on the kneecap or the back of the shin bone).

Korábbi kezelés

Patients cannot have had a corticosteroid injection into the affected knee in the past 3 months. No one can have had knee surgery before.

A részvétel fő kizáró okai

• Previous knee surgery or major knee injury.
• Rheumatic or autoimmune disease.
• Cancer (patients).
• Torn cruciate or collateral knee ligament, or knee osteoarthritis diagnosed in the past 6 months (healthy volunteers).
• Corticosteroid injection into the affected knee in the past 3 months (patients).

A regiszter feltételei, szó szerint

Mit akar kideríteni a vizsgálat

This prospective clinical study aims to establish normative values of knee ligament stiffness across different ethnic populations using shear wave elastography (SWE) and to investigate biomechanical alterations associated with knee osteoarthritis (OA). Healthy adults and patients with symptomatic knee OA will undergo standardized SWE examinations of the anterior cruciate ligament (ACL), posterior cruciate ligament (PCL), medial collateral ligament (MCL), and lateral collateral ligament (LCL), together with clinical assessments. For patients who subsequently receive clinically indicated ultrasound-guided injection therapy, follow-up SWE and clinical evaluations will be performed to investigate changes in ligament stiffness after treatment.

A vizsgálat 3 csoportja

• Healthy Controls

  Healthy adults without knee pain or major systemic disease undergoing standardized clinical assessment and bilateral knee ligament shear wave elastography.

  Kezelés: Shear Wave Elastography

• Symptomatic Knee Osteoarthritis

  Adults with symptomatic radiographic knee osteoarthritis undergoing baseline clinical assessment, physical examination, and bilateral knee ligament shear wave elastography.

  Kezelés: Shear Wave Elastography

• Knee Osteoarthritis After Injection Therapy

  Participants with symptomatic knee osteoarthritis who subsequently receive clinically indicated ultrasound-guided injection therapy and undergo follow-up clinical and shear wave elastography assessments after treatment.

  Kezelés: Shear Wave Elastography és Ultrasound-Guided Injection Therapy