Purpose to Evaluate the Effectiveness of the Superovulation Stimulation Protocol Using Human Chorionic Gonadotropin (hCG) by Demonstrating Its Equivalence to Standard Controlled Ovarian Stimulation Protocols in Terms of Oocytes Retrieved, Blastulation While Maintaining an Economic Advantage

MI-összefoglaló

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The trial is looking for women aged 18 to 40 who need ovary stimulation as part of IVF or other assisted reproduction. It compares a lower-cost hCG protocol with the standard medicine protocol.

Életkor

18 to 40 years

Nem

Women only

A betegség stádiuma

Infertility with a medical reason for ovary stimulation in an IVF or assisted reproduction program. Any level of egg reserve can join.

Biomarker vagy leletérték

Body Mass Index (BMI) up to 35 kg/m².

A részvétel fő kizáró okai

• Endometriomas (cysts of endometriosis) in the ovaries
• Past severe Ovarian Hyperstimulation Syndrome (OHSS), an overreaction of the ovaries
• Severe hormone (endocrine) disorders
• Cancer now or in the past
• Severe male partner infertility (cryptozoospermia), or any medical reason that rules out hormone stimulation

A regiszter feltételei, szó szerint

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• 18 és 40 év között vagy?IgenNem

Mit akar kideríteni a vizsgálat

This study evaluates a more affordable medication protocol for ovarian stimulation during in vitro fertilization (IVF). Standard IVF protocols use medications called gonadotropins to stimulate the ovaries to produce multiple eggs, but these medications can be very expensive and create a barrier to treatment. This clinical trial tests whether substituting a significant portion of these standard medications with human chorionic gonadotropin (hCG) is just as effective. Researchers will compare the number and quality of eggs and embryos produced by women using the experimental hCG protocol versus those using the standard gonadotropin protocol. The main goal is to determine if the hCG method can provide similar clinical outcomes and safety profiles while significantly reducing the overall financial cost of IVF treatment.

A vizsgálat 2 csoportja

• hCG ProtocolA vizsgált kezelés

  atients in this group undergo ovarian stimulation where human chorionic gonadotropin (hCG) replaces standard gonadotropins (or a significant portion of them) once the main cohort of follicles reaches 11-12 mm in size. This arm utilizes a fixed gonadotropin-releasing hormone (GnRH) antagonist protocol starting on day 6 of stimulation and a dual trigger for final maturation.

  Kezelés: Human Chorionic Gonadotropin (hCG), GnRH antagonist, Dual trigger (human chorionic gonadotropin plus GnRH-agonist) és Gonadotropins (FSH or FSH/LH)

• Standard ProtocolMár használt kezelés, összehasonlításként

  Patients in this group undergo standard controlled ovarian stimulation using continuous administration of gonadotropins. This arm also utilizes a fixed gonadotropin-releasing hormone (GnRH) antagonist protocol starting on day 6 of stimulation and a dual trigger for final maturation

  Kezelés: GnRH antagonist, Dual trigger (human chorionic gonadotropin plus GnRH-agonist) és Gonadotropins (FSH or FSH/LH)