Psilocybin for Methamphetamine Use Disorder

Ki vehet részt

• Age 18+
• DSM-5 moderate or severe Methamphetamine Use Disorder
• Severity of Dependence Scale score ≥ 4
• Methamphetamine use on more than 7 of the past 30 days and more than one positive urine test before randomization
• A goal of complete abstinence on the Thoughts About Abstinence questionnaire
• Able to read, write, and speak English
• A friend or family member available for post-session release
• Good general health by history and physical
• Confirmed pre-dose abstinence of at least 24 hours (clinically assessed)

Ki nem vehet részt

• Regular use of centrally acting serotonergic medications or MAO inhibitors (washout/re-screen permitted)
• Psychedelic use in the past 3 years, more than 3 lifetime psychedelic occasions, more than 3 lifetime ketamine or MDMA occasions, or any prior 5-MeO-DMT or ibogaine use
• Current psychiatric diagnoses other than a mild substance use disorder or tobacco/nicotine use disorder
• Current hypertension (>140/90 at rest)
• Personal history of any psychotic or bipolar I/II disorder, or a first- or second-degree relative with such
• Pregnancy or breastfeeding, or not using effective contraception
• Current suicidal or homicidal ideation
• Plan to relocate within 6 months