Még nem keres résztvevőt itt: Egyesült Államok4. fázis

Assessing Trauma-related Links Between Affective and Metabolic Systems

A legfontosabb adatok

Ki végzi: VA Office of Research and Development
Hol: Seattle (Egyesült Államok)A helyszín megnézése
Azonosító: NCT07862712
Állapot: Toborzás még nem indult
Fázis: 4. fázis
Résztvevők: 70 fő, tervezett
Kezdés: 2027. márc. 1.
Várható befejezés: 2032. dec. 31.
A vizsgálat típusa: Beavatkozással járó
A vizsgált kezelések: prazosin
A regiszteradat frissítve: 2026. október 15.

Ki vehet részt

Életkor: 21 év – 75 év
Nem: Nők és férfiak
Egészséges önkéntesek: Nem vehetnek részt

A regiszter feltételei, szó szerint

Mind a 14 feltétel megnézéseKevesebb

Ki vehet részt

Veteran of the US military
Diagnosis of post-traumatic stress disorder (PTSD) defined by Diagnostic and Statistical Manual of Mental Disorders (DSM-5) symptom count on Clinician-Administered PTSD Scale for DSM-5 (CAPS-5)

Ki nem vehet részt

Any form of diabetes as defined by the American Diabetes Association. Exceptions may be made for participants with previously undiagnosed, early, asymptomatic Type 2 Diabetes Mellitus (T2DM) who meet American Diabetes Association criteria for diabetes during study screening who wish to be included
Current use or use within the past 2 weeks of a medication with significant 1-AR or 2-AR activity (prazosin, doxazosin, alfuzosin, clonidine, guanfacine), or opiates
Ongoing or initiation of new treatment with evidence-based trauma-focused therapy for post-traumatic stress disorder (PTSD) within 2 weeks of baseline. Supportive psychotherapy may be continued during the study
Diagnosis of DSM-5-defined bipolar I, schizophrenia spectrum or other psychotic disorders (by MINI)
Diagnosis of dementia or related progressive neurocognitive disorder, based on clinical records
Diagnosis of moderate or severe substance use disorder (except for caffeine and nicotine) during the preceding 3 months
History of moderate or severe Traumatic Brain Injury (TBI) as defined by the Ohio State University TBI Identification Method
Current enrollment in another interventional trial for post-traumatic stress disorder (PTSD)
Current use or use within the past 3 months of antipsychotics, glucocorticoid medications, or glucose-lowering medications, including but not limited to metformin and GLP-1 agonists
Contraindication to prazosin
Increased risk of suicide that necessitates inpatient treatment, intensive outpatient care, or treatment excluded by the protocol
Pregnancy or lactation, or anticipated pregnancy at any point during study participation

Nézd meg, megfelelhetsz-e

Magadról válaszolj. Ez nem döntés: hogy részt vehetsz-e, azt csak a vizsgálat csapata mondhatja meg.

21 és 75 év között vagy?

Helyszínek itt: Egyesült Államok

VA Puget Sound Health Care System Seattle Division, Seattle, WASeattle, Egyesült ÁllamokContact: Katharine J Liang, MD PhDToborzás még nem indult

A vizsgálatról

Mit akar kideríteni a vizsgálat

KEY INFORMATION: The purpose of this study is to understand how insulin resistance (how your body processes sugar) and PTSD might be related. The goal is to improve the health of Veterans in three ways:

A teljes eredeti leírásKevesebb

1. Understanding health risks: The investigators want to learn why Veterans with post-traumatic stress disorder (PTSD) are more likely to develop medical problems related to insulin resistance, such as diabetes. 2. Testing effects of a medication: The investigators are testing whether prazosin, a medication that studies have shown may address some PTSD symptoms, can also improve how the body responds to insulin. If it does, this could point to a specific biological pathway that could be targeted for development of new treatments to prevent insulin resistance and diabetes in Veterans with PTSD. 3. Links to depression. The investigators will also look at whether insulin sensitivity affects depression symptoms in people with PTSD. This may inform future research into treatments for PTSD.