Cardiocentric Inotropic Optimization in Spinal Cord Injury

MI-összefoglaló

A vizsgálat saját részvételi feltételeiből. Gép olvasta ki az oldalon álló regiszterszövegből, ezért tévedhet. Hogy ki vehet részt, azt a lenti regiszterszöveg és a vizsgálat csapata dönti el.

The trial is looking for adults with a recent spinal cord injury in the neck or upper back caused by trauma. It tests switching blood pressure support from norepinephrine to dobutamine.

Életkor

18 Years to 75 Years

Nem

All sexes can join.

A betegség stádiuma

Acute traumatic spinal cord injury at bony spinal levels C0 to T1 (inclusive). The injury must be complete (AIS A) or incomplete (AIS B).

Korábbi kezelés

At the time of the switch, people must be on norepinephrine only for blood pressure, for the 4 hours before. They must already have an arterial line and a central venous catheter (CVC) as part of their usual care.

A részvétel fő kizáró okai

• Heart disease or heart-lung problems, including uncontrolled high blood pressure (Type 2 Diabetes is allowed)
• Brain injury severe enough to block testing of the spinal cord injury
• Bulge (aneurysm) of the chest aorta, aortic stenosis, unstable angina, or heart attack in the past 2 days
• Pregnancy
• Needing other blood pressure drugs besides norepinephrine in the 4 hours before the switch

A regiszter feltételei, szó szerint

Nézd meg, megfelelhetsz-e

Magadról válaszolj. Ez nem döntés: hogy részt vehetsz-e, azt csak a vizsgálat csapata mondhatja meg.

• 18 és 75 év között vagy?IgenNem

Mit akar kideríteni a vizsgálat

The first hours-to-day following acute traumatic cervical SCI represent a critical period of time to optimize hemodynamic management. After a spinal cord injury, cardiovascular function is affected. Maintaining blood pressure becomes is an important part of treatment as it supports recovery of the injured spinal cord. Blood pressure is most often increased using vasopressors, such as norepinephrine. Although these drugs help maintain blood flow, they may also lead to increased bleeding in the injury site, making the lesion worse. Alternatively, dobutamine, a medication that helps the heart pump more effectively, has shown to maintain blood pressure and improve prefusion at the injury site. This study will assess dobutamine capacity to maintain blood pressure acutely post injury.

A vizsgálat csoportja

• Dobutamine CrossoverA vizsgált kezelés

  The main procedure in this study is a "cross-over" from NE to DOB, in which we will assess cardiac function while switching the hemodynamic management from NE to DOB.