The Microbiome in Uveitis and Pediatric Inflammatory Diseases

MI-összefoglaló

A vizsgálat saját részvételi feltételeiből. Gép olvasta ki az oldalon álló regiszterszövegből, ezért tévedhet. Hogy ki vehet részt, azt a lenti regiszterszöveg és a vizsgálat csapata dönti el.

The trial is looking for children treated at Robert-Debré Hospital who have noninfectious uveitis (eye inflammation not caused by infection) or another childhood inflammatory disease. Healthy children, such as siblings of patients or children of hospital staff, can also join as a comparison group.

Életkor

1 Day to 17 Years (under 18)

Nem

All sexes

A betegség stádiuma

Noninfectious uveitis, or a childhood inflammatory disease without uveitis: connective tissue disorders, granulomatosis, juvenile idiopathic arthritis or childhood vasculitis (inflamed blood vessels). Healthy children can join as controls.

A részvétel fő kizáró okai

• The child or parents object to taking part

A regiszter feltételei, szó szerint

Mit akar kideríteni a vizsgálat

Chronic, noninfectious uveitis in children, associated with various systemic inflammatory diseases, carries a high risk of vision loss. Intestinal dysbiosis and the translocation of bacterial peptidoglycans (PG) that activate innate receptors recognizing PG could represent a common initiating mechanism, independent of the underlying disease. Studying these biological signatures in comparative cohorts could lead to a better understanding of the onset of uveitis and the development of targeted diagnostic and therapeutic strategies.

A vizsgálat 3 csoportja

• patients with noninfectious uveitis

  including pediatric connective tissue disorders, granulomatosis, idiopathic juvenile arthritis without uveitis, pediatric vasculitis, and chronic inflammatory bowel diseases. These conditions were selected because of their inflammatory and/or autoimmune nature, making it possible to determine whether fecal peptidoglycan signatures

• patients with another inflammatory disease

  without uveitis (connective tissue disease, granulomatosis, juvenile idiopathic arthritis, pediatric vasculitis, chronic inflammatory bowel disease)

• healthy children living in the same household as those who are sick

  Siblings of patients or children of hospital staff, who may be included as healthy control groups