A MOST Framework Trial Evaluating the MOst effectiVe Exercise Types for Blood Pressure Control

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A vizsgálat 18 és 44 év közötti, kezeletlen, I. stádiumú magas vérnyomású felnőtteket keres, akik keveset mozognak. Azt vizsgálja, hogy melyik edzéstípus csökkenti a vérnyomást.

Életkor

18 és 44 év között

Nem

Minden nem csatlakozhat.

A betegség stádiuma

Kezeletlen, I. stádiumú magas vérnyomás: 130-139/80-89 Hgmm, az elmúlt évben legalább 2 járóbeteg-vizitnél rögzítve. Az otthoni vérnyomás átlaga 7 napon át szintén 130-139/80-89 Hgmm.

Korábbi kezelés

Jelenleg nem szed vérnyomáscsökkentő gyógyszert. Az elmúlt évben nem használt GLP-1 receptor agonistát.

Biomarker vagy leletérték

A PREVENT kockázatszámító szerint a becsült 10 éves szív- és érrendszeri kockázat 7,5% alatti. A testtömegindex 18,5 és 39,9 kg/m2 között van.

A részvétel fő kizáró okai

• GLP-1 receptor agonista használata az elmúlt évben
• 15 fontnál nagyobb testsúlyváltozás az elmúlt 3 hónapban
• Terhesség vagy terhességtervezés 6 hónapon belül
• Cukorbetegség, krónikus vesebetegség, COPD vagy szív- és érrendszeri betegség
• Aktív daganatos betegség vagy jelenlegi daganatkezelés

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• 18 és 44 év között vagy?IgenNem

Mit akar kideríteni a vizsgálat

Exercise is known to prevent nearly one in three cases of hypertension and slow its progression in young adults, but we do not know which specific exercise types are most effective. The main objective of this study is to determine which exercise prescription (ExRx) intervention component(s) alone or in combination most effectively lower systolic BP in young adults with stage I hypertension, identify the vascular mechanisms underlying these changes, and guide the development of optimized exercise-based prescription packages for effective hypertension control in this population.

A vizsgálat 8 csoportja

• Core + AT + DRT + IRTA vizsgált kezelés

  Participants receive the core intervention (Fitbit activity tracker and standard blood pressure health education) plus all three exercise components for 6 months: aerobic training (AT), dynamic resistance training (DRT), and isometric resistance training (IRT). AT: 4 sessions/week of moderate-to-vigorous endurance exercise, progressing from 40-59% to 60-89% heart rate reserve. DRT: 3 sessions/week of 6 exercises, 3 sets each, progressing from 50% to 70-80% of 1-repetition maximum. IRT: 3 sessions/week of a 3-exercise circuit, 4 sets of holds progressing to 2 minutes, at 30% maximum voluntary contraction (upper body) and 95% peak heart rate (lower body). Each component includes 1 trainer-supervised videoconference session per week; remaining sessions are unsupervised and guided by manualized videos.

  Kezelés: Core intervention (Fitbit tracking and BP health education), Aerobic training (AT), Dynamic resistance training (DRT) és Isometric resistance training (IRT)

• Core + AT + DRTA vizsgált kezelés

  Participants receive the core intervention (Fitbit activity tracker and standard blood pressure health education) plus aerobic training (AT) and dynamic resistance training (DRT) for 6 months. AT: 4 sessions/week of moderate-to-vigorous endurance exercise, progressing from 40-59% to 60-89% heart rate reserve. DRT: 3 sessions/week of 6 exercises, 3 sets each, progressing from 50% to 70-80% of 1-repetition maximum. Each component includes 1 trainer-supervised videoconference session per week; remaining sessions are unsupervised and guided by manualized videos.

  Kezelés: Core intervention (Fitbit tracking and BP health education), Aerobic training (AT) és Dynamic resistance training (DRT)

• Core + AT + IRTA vizsgált kezelés

  Participants receive the core intervention (Fitbit activity tracker and standard blood pressure health education) plus aerobic training (AT) and isometric resistance training (IRT) for 6 months. AT: 4 sessions/week of moderate-to-vigorous endurance exercise, progressing from 40-59% to 60-89% heart rate reserve. IRT: 3 sessions/week of a 3-exercise circuit, 4 sets of holds progressing to 2 minutes, at 30% maximum voluntary contraction (upper body) and 95% peak heart rate (lower body). Each component includes 1 trainer-supervised videoconference session per week; remaining sessions are unsupervised and guided by manualized videos.

  Kezelés: Core intervention (Fitbit tracking and BP health education), Aerobic training (AT) és Isometric resistance training (IRT)

• Core + ATA vizsgált kezelés

  Participants receive the core intervention (Fitbit activity tracker and standard blood pressure health education) plus aerobic training (AT) for 6 months. AT: 4 sessions/week of moderate-to-vigorous endurance exercise (e.g., walking, stair climbing), progressing from 40-59% to 60-89% heart rate reserve. Includes 1 trainer-supervised videoconference session per week; remaining sessions are unsupervised and guided by manualized videos.

  Kezelés: Core intervention (Fitbit tracking and BP health education) és Aerobic training (AT)

• Core + DRT + IRTA vizsgált kezelés

  Participants receive the core intervention (Fitbit activity tracker and standard blood pressure health education) plus dynamic resistance training (DRT) and isometric resistance training (IRT) for 6 months. DRT: 3 sessions/week of 6 exercises, 3 sets each, progressing from 50% to 70-80% of 1-repetition maximum. IRT: 3 sessions/week of a 3-exercise circuit, 4 sets of holds progressing to 2 minutes, at 30% maximum voluntary contraction (upper body) and 95% peak heart rate (lower body). Each component includes 1 trainer-supervised videoconference session per week; remaining sessions are unsupervised and guided by manualized videos.

  Kezelés: Core intervention (Fitbit tracking and BP health education), Dynamic resistance training (DRT) és Isometric resistance training (IRT)

• Core + DRTA vizsgált kezelés

  Participants receive the core intervention (Fitbit activity tracker and standard blood pressure health education) plus dynamic resistance training (DRT) for 6 months. DRT: 3 sessions/week of 6 exercises (e.g., squat, chest press, lunges, shoulder press), 3 sets each, progressing from 50% to 70-80% of 1-repetition maximum. Includes 1 trainer-supervised videoconference session per week; remaining sessions are unsupervised and guided by manualized videos.

  Kezelés: Core intervention (Fitbit tracking and BP health education) és Dynamic resistance training (DRT)

• Core + IRTA vizsgált kezelés

  Participants receive the core intervention (Fitbit activity tracker and standard blood pressure health education) plus isometric resistance training (IRT) for 6 months. IRT: 3 sessions/week of a 3-exercise circuit (e.g., wall sit, plank, glute bridge), 4 sets of holds progressing to 2 minutes, at 30% maximum voluntary contraction (upper body) and 95% peak heart rate (lower body). Includes 1 trainer-supervised videoconference session per week; remaining sessions are unsupervised and guided by manualized videos.

  Kezelés: Core intervention (Fitbit tracking and BP health education) és Isometric resistance training (IRT)

• Core onlyA vizsgált kezelés

  Participants receive the core intervention only for 6 months: a wrist-worn Fitbit activity tracker for daily wear and standard blood pressure health education materials (videos and flyers adapted from NHLBI and the American Heart Association) delivered twice per month. No exercise components are prescribed.

  Kezelés: Core intervention (Fitbit tracking and BP health education)