ELATE Study: Evaluating Large-vessel Acute Thrombectomy in Extended Time Window

Ki vehet részt

• Age ≥ 18 years
• Presentation with acute ischemic stroke within 24 to 72 hours of stroke onset or last known well
• Baseline National Institutes of Health Stroke Scale (NIHSS) ≥ 8 (patients with an NIHSS score < 8 at admission who experienced neurological deterioration to an NIHSS score ≥ 8 were also included if they were 24 to 72 hours from the LKW at this point)
• Clinical diagnosis of AIS due to anterior circulation LVO (internal carotid artery (ICA) extracranial or intracranial segment, middle cerebral artery (MCA) M1 and proximal M2 segment) on computed tomography angiography (CTA) or magnetic resonance angiography (MRA)
• Imaging criteria: must fulfill at least one:; 1) Core-penumbra mismatch on computed tomography perfusion (CTP) or magnetic resonance perfusion (MRP) assessed: infarct core volume ≤ 70mL, mismatch ratio ≥ 1.8 and mismatch volume ≥ 15mL; 2) ASPECTS ≥6 on non-contrast computed tomography (CT) or diffusion-weighted imaging (DWI)
• Written informed consent (by patient or proxy, according to local requirements)

Ki nem vehet részt

• Pre-stroke modified Rankin Scale (mRS) score >2 (indicating previous disability)
• Intracranial hemorrhage identified by CT or magnetic resonance imaging (MRI)
• Any terminal illness such that the patient has a life expectancy of less than 1 year
• Patients with active cancer and undergoing treatment for cancer are excluded
• Pregnancy